N-(3,5-dichloro-2-hydroxyphenyl)-4-methoxy-3-[4-(2,2,2-trichloroethanoyl)-piperazin-1-yl]-benzenesulfonamide

Base Information

Chemical Name:N-(3,5-dichloro-2-hydroxyphenyl)-4-methoxy-3-[4-(2,2,2-trichloroethanoyl)-piperazin-1-yl]-benzenesulfonamide
CAS No.:1331830-34-2
Molecular Formula:C₁₉H₁₈Cl₅N₃O₅S
Molecular Weight:577.7
Hs Code.:

Synonyms:N-(3,5-dichloro-2-hydroxyphenyl)-4-methoxy-3-[4-(2,2,2-trichloroethanoyl)-piperazin-1-yl]-benzenesulfonamide

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Chemical Property of N-(3,5-dichloro-2-hydroxyphenyl)-4-methoxy-3-[4-(2,2,2-trichloroethanoyl)-piperazin-1-yl]-benzenesulfonamide

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Technology Process of N-(3,5-dichloro-2-hydroxyphenyl)-4-methoxy-3-[4-(2,2,2-trichloroethanoyl)-piperazin-1-yl]-benzenesulfonamide

There total 2 articles about N-(3,5-dichloro-2-hydroxyphenyl)-4-methoxy-3-[4-(2,2,2-trichloroethanoyl)-piperazin-1-yl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 527-62-8
2,4-dichloro-6-aminophenol

: 219963-60-7
4-methoxy-3-(4-(2,2,2-trichloroacetyl)piperazin-1-yl)benzene-1-sulfonyl chloride

: 1331830-34-2
N-(3,5-dichloro-2-hydroxyphenyl)-4-methoxy-3-[4-(2,2,2-trichloroethanoyl)-piperazin-1-yl]-benzenesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2011.06.090

Reference yield:

: 5464-78-8
1-(2-methoxyphenyl)piperazine hydrochloride

: 1331830-34-2
N-(3,5-dichloro-2-hydroxyphenyl)-4-methoxy-3-[4-(2,2,2-trichloroethanoyl)-piperazin-1-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4.17 h / 20 °C / Inert atmosphere

2: chlorosulfonic acid / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; chlorosulfonic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmc.2011.06.090

Reference yield: 74.0%

: 1331830-34-2
N-(3,5-dichloro-2-hydroxyphenyl)-4-methoxy-3-[4-(2,2,2-trichloroethanoyl)-piperazin-1-yl]-benzenesulfonamide

: 1331830-35-3
N-(3,5-dichloro-2-hydroxyphenyl)-4-methoxy-3-piperazin-1-yl-benzenesulfonamide

Guidance literature:: N-(3,5-dichloro-2-hydroxyphenyl)-4-methoxy-3-[4-(2,2,2-trichloroethanoyl)-piperazin-1-yl]-benzenesulfonamide; With potassium hydroxide; In tetrahydrofuran; at 20 ℃; for 20h;

With hydrogenchloride; In tetrahydrofuran; water; pH=7; Cooling with ice;
DOI:10.1016/j.bmc.2011.06.090