tert-butyl 3-(4-chloro-3-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(4-chloro-3-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate
CAS No.:1510865-82-3
Molecular Formula:C₁₇H₂₂ClNO₄
Molecular Weight:339.819
Hs Code.:

Synonyms:tert-butyl 3-(4-chloro-3-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate

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Chemical Property of tert-butyl 3-(4-chloro-3-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate

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Technology Process of tert-butyl 3-(4-chloro-3-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate

There total 5 articles about tert-butyl 3-(4-chloro-3-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 874219-46-2
(4-chloro-3-(ethoxycarbonyl)phenyl)boronic acid

: 1510865-67-4
tert-butyl 3-(2-((4-methoxyphenyl)sulfonyl)hydrazineylidene)azetidine-1-carboxylate

: 1510865-82-3
tert-butyl 3-(4-chloro-3-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate

Guidance literature:: With caesium carbonate; In 1,4-dioxane; at 110 ℃; for 18h; Inert atmosphere; Schlenk technique;
DOI:10.1021/jo402526z

Reference yield: 34.0%

: 874219-46-2
(4-chloro-3-(ethoxycarbonyl)phenyl)boronic acid

: 1510865-66-3
tert-butyl 3-(2-tosylhydrazineylidene)azetidine-1-carboxylate

: 1510865-82-3
tert-butyl 3-(4-chloro-3-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate

Guidance literature:: With caesium carbonate; In 1,4-dioxane; at 110 ℃; for 18h; Inert atmosphere; Schlenk technique;
DOI:10.1021/jo402526z

Reference yield:

: 76008-73-6
5-Bromo-2-chloro-benzoic acid ethyl ester

: 1510865-82-3
tert-butyl 3-(4-chloro-3-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene; potassium acetate / 1,4-dioxane / 22 h / 80 °C / Inert atmosphere; Schlenk technique

2: ammonium acetate; sodium periodate / acetone; water / 19 h / 20 °C

3: caesium carbonate / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere; Schlenk technique

With 1,1'-bis-(diphenylphosphino)ferrocene; sodium periodate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonium acetate; potassium acetate; caesium carbonate; In 1,4-dioxane; water; acetone;
DOI:10.1021/jo402526z