1510865-67-4

Basic information

• Product Name: tert-butyl 3-(2-((4-methoxyphenyl)sulfonyl)hydrazineylidene)azetidine-1-carboxylate
• Synonyms: tert-butyl 3-(2-((4-methoxyphenyl)sulfonyl)hydrazineylidene)azetidine-1-carboxylate
• CAS NO: 1510865-67-4
• Molecular Weight: 355.415
• Mol File: 1510865-67-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 3-(2-((4-methoxyphenyl)sulfonyl)hydrazineylidene)azetidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-(2-((4-methoxyphenyl)sulfonyl)hydrazineylidene)azetidine-1-carboxylate(1510865-67-4)
• EPA Substance Registry System: tert-butyl 3-(2-((4-methoxyphenyl)sulfonyl)hydrazineylidene)azetidine-1-carboxylate(1510865-67-4)

Safety Data

• Hazardous Substances Data: 1510865-67-4(Hazardous Substances Data)

Upstream product

• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 398489-26-4 tert-butyl 3-oxoazetidine-1-carboxylate 
• 1950-68-1 4-methoxybenzenesulfonyl hydrazide 

Downstream Products

• 1510865-82-3 tert-butyl 3-(4-chloro-3-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate 
• 1044507-62-1 tert-butyl 3-(4'-methylphenyl)azetidine-1-carboxylate 
• 1510865-75-4 tert-butyl 3-(4-methoxyphenyl)azetidine-1-carboxylate 
• 1510865-80-1 tert-butyl 3-(3-nitrophenyl)azetidine-1-carboxylate 
• 1412977-14-0 tert-butyl 3-(3-fluorophenyl)azetidine-1-carboxylate 

Relevant articles and documents

5-HT2A AGONISTS FOR USE IN TREATMENT OF DEPRESSION

The present invention relates to agonists of the 5-HT2A serotonin receptors and their medical uses. In one aspect the invention relates to 5-HT2A agonists of formula (I). In second aspect, the invention relates to selective 5-HT2A agonists of formula (II). In another aspect, the invention relates to mixed 5-HT2A/5-HT2C agonists of formula (III). In yet another aspect, the invention relates to 5-HT2A agonists for use in the treatment of a depressive disorder, more particular a 5-HT2A agonist for the use in the treatment of treatment-resistant depression.

Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids

The coupling of aromatic moieties with saturated heterocyclic partners is currently an area of significant interest for the pharmaceutical industry. Herein, we present a procedure for the metal-free coupling of 4-, 5-, and 6-membered saturated heterocyclic p-methoxyphenyl (PMP) sulfonylhydrazones with aryl and heteroaromatic boronic acids. This procedure enables a simple, two-step synthesis of a range of functionalized sp2-sp3 linked bicyclic building blocks, including oxetanes, piperidines, and azetidines, from their parent ketones.