3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl methoxyacetate

Base Information

Chemical Name:3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl methoxyacetate
CAS No.:1036712-91-0
Molecular Formula:C₃₁H₃₃FN₆O₆
Molecular Weight:604.638
Hs Code.:

Synonyms:3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl methoxyacetate

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Chemical Property of 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl methoxyacetate

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Technology Process of 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl methoxyacetate

There total 6 articles about 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl methoxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 38870-89-2
Methoxyacetyl chloride

: 1036712-77-2
4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide

: 1036712-91-0
3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl methoxyacetate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 72h;

Reference yield:

: 725685-92-7
3-(5-amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid ethyl ester

: 1036712-91-0
3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl methoxyacetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrahydrofuran / 20 °C

2: triethylamine / tetrahydrofuran / 20 °C

3: sodium tetrahydroborate / ethanol / 20 °C

4: pyridine / dichloromethane / 72 h / 0 - 20 °C

With pyridine; sodium tetrahydroborate; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 59997-51-2
trimethylacetylacetonitrile

: 1036712-91-0
3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl methoxyacetate

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 18 h / 90 °C

2: potassium carbonate / tetrahydrofuran / 20 °C

3: triethylamine / tetrahydrofuran / 20 °C

4: sodium tetrahydroborate / ethanol / 20 °C

5: pyridine / dichloromethane / 72 h / 0 - 20 °C

With pyridine; sodium tetrahydroborate; sulfuric acid; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;