7,7-dimethyl-2'-phenyl-pyrazol-3'-one-bicyclo[2.2.1]heptane

Base Information

• Chemical Name: 7,7-dimethyl-2'-phenyl-pyrazol-3'-one-bicyclo[2.2.1]heptane
• CAS No.: 263722-72-1
• Molecular Formula: C₁₆H₂₀N₂O
• Molecular Weight: 256.348
• Mol file: 263722-72-1.mol

Synonyms:7,7-dimethyl-2'-phenyl-pyrazol-3'-one-bicyclo[2.2.1]heptane

Chemical Property of 7,7-dimethyl-2'-phenyl-pyrazol-3'-one-bicyclo[2.2.1]heptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7,7-dimethyl-2'-phenyl-pyrazol-3'-one-bicyclo[2.2.1]heptane

There total 7 articles about 7,7-dimethyl-2'-phenyl-pyrazol-3'-one-bicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

7,7-dimethyl-2'-phenyl-2',4'-dihydropyrazol-3'-one-bicyclo[2.2.1]heptane (263722-71-0) → 7,7-dimethyl-2'-phenyl-pyrazol-3'-one-bicyclo[2.2.1]heptane (263722-72-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

DOI:10.1021/ol990315n

Reference yield: 82.0%

methanol (67-56-1) + 2-[(R)-2-((1S,5R,7R)-10,10-Dimethyl-2-oxo-3-phenyl-3,4-diaza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-aziridin-1-yl]-isoindole-1,3-dione → 7,7-dimethyl-2'-phenyl-pyrazol-3'-one-bicyclo[2.2.1]heptane (263722-72-1) + (2R)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-aziridine-2-carboxylic acid methyl ester

Guidance literature:

With dmap; at 40 ℃; for 4h;

DOI:10.1021/jo005621p

Reference yield: 75.0%

(1S,5R,7R)-4-((R)-3-tert-Butyl-4,5-dihydro-isoxazole-5-carbonyl)-10,10-dimethyl-3-phenyl-3,4-diaza-tricyclo[5.2.1.01,5]decan-2-one (265098-31-5) → (R)-(-)-3-(1,1-dimethylethyl)-5-(hydroxymethyl)-2-isoxazoline (108169-80-8) + 7,7-dimethyl-2'-phenyl-pyrazol-3'-one-bicyclo[2.2.1]heptane (263722-72-1)

Guidance literature:

With L-Selectride; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4039(99)02316-3

upstream raw materials:

(1S,5R,7R)-4-((R)-3-tert-Butyl-4,5-dihydro-isoxazole-5-carbonyl)-10,10-dimethyl-3-phenyl-3,4-diaza-tricyclo[5.2.1.0^1,5]decan-2-one

(1S,5R,7R)-10,10-Dimethyl-3-phenyl-4-((R)-3-phenyl-4,5-dihydro-isoxazole-5-carbonyl)-3,4-diaza-tricyclo[5.2.1.0^1,5]decan-2-one

7,7-dimethyl-2'-phenyl-2',4'-dihydropyrazol-3'-one-bicyclo[2.2.1]heptane

methanol

Downstream raw materials:

(1S,5R,7R)-4-Acryloyl-10,10-dimethyl-3-phenyl-3,4-diaza-tricyclo[5.2.1.0^1,5]decan-2-one

(1S,5R,7R)-10,10-Dimethyl-4-((E)-pent-2-enoyl)-3-phenyl-3,4-diaza-tricyclo[5.2.1.0^1,5]decan-2-one

C₂₈H₂₈N₂O₂

C₂₂H₂₄N₂O₂S