(2RS,cis)-3,4,4a,5,6,7-hexahydro-4a,8-dimethyl-2-(phenylseleno)-1(2H)-naphthalenone

Base Information

Chemical Name:(2RS,cis)-3,4,4a,5,6,7-hexahydro-4a,8-dimethyl-2-(phenylseleno)-1(2H)-naphthalenone
CAS No.:124128-00-3
Molecular Formula:C₁₈H₂₂OSe
Molecular Weight:333.332
Hs Code.:

Synonyms:(2RS,cis)-3,4,4a,5,6,7-hexahydro-4a,8-dimethyl-2-(phenylseleno)-1(2H)-naphthalenone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2RS,cis)-3,4,4a,5,6,7-hexahydro-4a,8-dimethyl-2-(phenylseleno)-1(2H)-naphthalenone

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Technology Process of (2RS,cis)-3,4,4a,5,6,7-hexahydro-4a,8-dimethyl-2-(phenylseleno)-1(2H)-naphthalenone

There total 3 articles about (2RS,cis)-3,4,4a,5,6,7-hexahydro-4a,8-dimethyl-2-(phenylseleno)-1(2H)-naphthalenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57232-69-6
3-(4-oxopentyl)-2-cyclohexen-1-one

: 124128-00-3
(2RS,cis)-3,4,4a,5,6,7-hexahydro-4a,8-dimethyl-2-(phenylseleno)-1(2H)-naphthalenone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) CuI, 2.) p-TsOH*H₂O / 2.) molecular sieves (3 Angstroem) / 1a.) ether, -78 deg C, 1.5 h, 1b.) ice-bath, 1 h, 2.) benzene, 4 h at reflux

2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 15 min, 2.) -78 deg C, 30 min

With copper(l) iodide; toluene-4-sulfonic acid; lithium diisopropyl amide; 3 A molecular sieve;
DOI:10.1021/jo00290a053

Reference yield:

: 124127-98-6
3,4,4a,5,6,8a-hexahydro-4a,8-dimethyl-1(2H)-naphthalenone

: 124128-00-3
(2RS,cis)-3,4,4a,5,6,7-hexahydro-4a,8-dimethyl-2-(phenylseleno)-1(2H)-naphthalenone

Guidance literature:: Multi-step reaction with 2 steps

1: RhCl₃*3H₂O / ethanol; benzene / 28 h / Heating

2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 15 min, 2.) -78 deg C, 30 min

With lithium diisopropyl amide; rhodium(III) chloride; In ethanol; benzene;
DOI:10.1021/jo00290a053

Reference yield:

: 5707-04-0
Phenylselenyl chloride

: 62335-54-0
3,4,4a,5,6,7-hexahydro-4a,8-dimethyl-1(2H)-naphthalenone

: 124128-00-3
(2RS,cis)-3,4,4a,5,6,7-hexahydro-4a,8-dimethyl-2-(phenylseleno)-1(2H)-naphthalenone

: 124127-99-7
(2RS,trans)-3,4,4a,5,6,7-hexahydro-4a,8-dimethyl-2-(phenylseleno)-1(2H)-naphthalenone

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, -78 deg C, 1.5 h, 2) THF, -30 deg C, 2 h;