Quinoline-3-carboxylic acid [(R)-1-(benzyl-methyl-carbamoyl)-2-(1H-indol-3-yl)-ethyl]-amide

Base Information

Chemical Name:Quinoline-3-carboxylic acid [(R)-1-(benzyl-methyl-carbamoyl)-2-(1H-indol-3-yl)-ethyl]-amide
CAS No.:127368-59-6
Molecular Formula:C₂₉H₂₆N₄O₂
Molecular Weight:462.551
Hs Code.:

Synonyms:Quinoline-3-carboxylic acid [(R)-1-(benzyl-methyl-carbamoyl)-2-(1H-indol-3-yl)-ethyl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Quinoline-3-carboxylic acid [(R)-1-(benzyl-methyl-carbamoyl)-2-(1H-indol-3-yl)-ethyl]-amide

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Technology Process of Quinoline-3-carboxylic acid [(R)-1-(benzyl-methyl-carbamoyl)-2-(1H-indol-3-yl)-ethyl]-amide

There total 2 articles about Quinoline-3-carboxylic acid [(R)-1-(benzyl-methyl-carbamoyl)-2-(1H-indol-3-yl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6480-68-8
quinoline-3-carboxylic acid

: (R)-2-Amino-N-benzyl-3-(1H-indol-3-yl)-N-methyl-propionamide; hydrochloride

: 127368-59-6
Quinoline-3-carboxylic acid [(R)-1-(benzyl-methyl-carbamoyl)-2-(1H-indol-3-yl)-ethyl]-amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 4 - 20 ℃;
DOI:10.1021/jm00116a002

Reference yield:

: 103-67-3
benzyl-methyl-amine

: 127368-59-6
Quinoline-3-carboxylic acid [(R)-1-(benzyl-methyl-carbamoyl)-2-(1H-indol-3-yl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 4 N HCl / dioxane / 1 h

2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCl), HOBt, triethylamine (TEA) / CH₂Cl₂ / 4 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00116a002