6480-68-8

Usage

Uses

Used in Pharmaceutical Industry:
3-Quinolinecarboxylic acid is used as an antimicrobial agent for its ability to inhibit the growth of various bacteria. This makes it a valuable compound in the development of new drugs and treatments for bacterial infections.
Used in Research and Development:
In the field of research and development, 3-Quinolinecarboxylic acid serves as a key compound for studying its potential applications in medicine and other industries. Its antimicrobial properties make it an interesting subject for further investigation into its effectiveness against different types of bacteria and possible integration into various products.
Used in Agricultural Industry:
3-Quinolinecarboxylic acid can also be utilized in the agricultural industry as a potential antimicrobial agent to protect crops from bacterial infections, thereby increasing yield and reducing the need for chemical pesticides.
Used in Cosmetics Industry:
Due to its antimicrobial properties, 3-Quinolinecarboxylic acid can be employed in the cosmetics industry as a preservative to extend the shelf life of products and maintain their safety and efficacy.

InChI:InChI=1/C10H7NO2/c12-10(13)8-5-7-3-1-2-4-9(7)11-6-8/h1-6H,(H,12,13)/p-1

Upstream product

• 1873-54-7 3-ethyl quinoline 
• 5332-24-1 3-bromoquinoline 
• 34846-64-5 3-cyanoquinoline 
• 33021-53-3 1-quinolin-3-yl-ethanone 
• 4945-38-4 2-hydroxymethylquinoline-3-carboxylic acid lactone 
• 13669-42-6 3-quinolylcarboxaldehyde 
• 529-23-7 o-aminobenzaldehyde 
• 201230-82-2 carbon monoxide 
• 17609-48-2 (R)-2-phenylglycine ethyl ester hydrochloride 
• 120277-70-5 3-(bromomethyl)quinoline 
• 580-18-7 3-hydroxyquinoline 
• 124-38-9 carbon dioxide 
• 584-08-7 potassium carbonate 
• 612-58-8 3-methylquinoline 

Downstream Products

• 104637-19-6 N-(3-Chinolincarbonyl)-N-methyl-phenylglycinamid 
• 138354-46-8 Quinoline-3-carboxylic acid (3,3-diphenyl-allyl)-amide 
• 127368-41-6 Quinoline-3-carboxylic acid [(R)-1-benzylcarbamoyl-2-(1H-indol-3-yl)-ethyl]-amide 
• 127368-59-6 Quinoline-3-carboxylic acid [(R)-1-(benzyl-methyl-carbamoyl)-2-(1H-indol-3-yl)-ethyl]-amide 
• 127368-56-3 (Benzyl-{(R)-3-(1H-indol-3-yl)-2-[(quinoline-3-carbonyl)-amino]-propionyl}-amino)-acetic acid ethyl ester 
• 127368-52-9 Quinoline-3-carboxylic acid [2-(5-benzyloxy-1H-indol-3-yl)-1-dipentylcarbamoyl-ethyl]-amide 
• 127368-63-2 Quinoline-3-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-((R)-1-phenyl-ethylcarbamoyl)-ethyl]-amide 
• 136675-73-5 Quinoline-3-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-amide 
• 136631-70-4 {(R)-3-(1H-Indol-3-yl)-2-[(quinoline-3-carbonyl)-amino]-propionylamino}-phenyl-acetic acid ethyl ester 
• 136631-71-5 (R)-{(R)-3-(1H-Indol-3-yl)-2-[(quinoline-3-carbonyl)-amino]-propionylamino}-phenyl-acetic acid ethyl ester 
• 124502-70-1 Quinoline-3-carboxylic acid [4-(4-benzhydryl-piperazin-1-yl)-butyl]-amide 
• 13669-51-7 3-Hydroxymethylquinoline 
• 50741-46-3 ethyl 3-quinolinecarboxylate 
• 13669-42-6 3-quinolylcarboxaldehyde 

Relevant academic research and scientific papers

Convenient synthesis of 3-Hydroxyquinolines via dakin oxidation: A short synthesis of Jineol

A convenient synthesis of 3-hydroxyquinolines has been described via unprecedented Dakin oxidation of quinoline-3-carboxaldehydes. Subsequently, application of the methodology to a high yielding synthesis of quinoline alkaloid Jineol (1) is reported.

Method for preparing aromatic carboxylic acid compound

The invention discloses a method for preparing an aromatic carboxylic acid compound. The method comprises the following steps: 1) heating carbon dioxide and hydrosilane in the presence of a copper catalyst in a reaction medium A; and 2) adding a reaction medium B, aryl halide, a palladium catalyst and a base to the reaction mixture in the step 1), sealing the reaction system, and performing a heating reaction. The method has the advantages that raw materials are simple and easy to obtain, the raw materials are cheap and stable, the catalyst is common, easy to obtain and stable, the reaction conditionsaremild, the aftertreatment is simple, the yield is high, and the like.

Nickel-catalyzed carboxylation of aryl and heteroaryl fluorosulfates using carbon dioxide

The development of efficient and practical methods to construct carboxylic acids using CO2 as a C1 synthon is of great importance. Nickel-catalyzed carboxylation of aryl fluorosulfates and heteroaryl fluorosulfates with CO2 is described, affording arene carboxylic acids with good to excellent yields under mild conditions. In addition, a one-pot phenol fluorosulfation/carboxylation is developed.

Tandem one-pot CO2 reduction by PMHS and silyloxycarbonylation of aryl/vinyl halides to access carboxylic acids

The present study discloses the synthesis of aryl/vinyl carboxylic acids from Csp2-bound halides (Cl, Br, I) in a carbonylative path by using silyl formate (from CO2 and hydrosilane) as an instant CO-surrogate. Hydrosilane provides hydride for reduction and its oxidation product silanol serves as a coupling partner. Mono-, di-, and tri-carboxylic acids were obtained from the corresponding aryl/vinyl halides.

Carboxylation of Aromatic and Aliphatic Bromides and Triflates with CO2 by Dual Visible-Light–Nickel Catalysis

We report the efficient carboxylation of bromides and triflates with K2CO3 as the source of CO2 in the presence of an organic photocatalyst in combination with a nickel complex under visible light irradiation at room temperature. The reaction is compatible with a variety of functional groups and has been successfully applied to the synthesis and derivatization of biologically active molecules. In particular, the carboxylation of unactivated cyclic alkyl bromides proceeded well with our protocol, thus extending the scope of this transformation. Spectroscopic and spectroelectrochemical investigations indicated the generation of a Ni0 species as a catalytic reactive intermediate.

Effective palladium-catalyzed hydroxycarbonylation of aryl halides with substoichiometric carbon monoxide

A protocol for the Pd-catalyzed hydroxycarbonylation of aryl iodides, bromides, and chlorides has been developed using only 1-5 mol % of CO, corresponding to a pCO as low as 0.1 bar. Potassium formate is the only stoichiometric reagent, acting as a mildly basic nucleophile and a reservoir of CO. The substoichiometric CO could be delivered to the reaction from an acyl-Pd(II) precatalyst, which provides both the CO and an active catalyst, and thereby obviates the need for handling a toxic gas.

Preparation of 4,7-diphenyl-1,10-phenanthroline-2,9-dicarboxylic acid catalyzed by iron(III)porphyrins with (diacetoxyiodo)benzene

Using iron(III)porphyrins in combination with (diacetoxyiodo)benzene allows for the conversion of 2,9-bis(bromomethyl)-4,7-diphenyl-1,10-phenanthroline into 4,7-diphenyl-1,10-phenanthroline-2,9-dicarboxylic acid. This method provides a cost-effective and environmentally-friendly oxidation procedure using less toxic PhI(OAc)2 and biologically relevant iron(III)porphyrins. The catalytic activity of five kinds of iron-metallated functional porphyrins were investigated using different oxidants, including air, H2O 2, PhI(OAc)2, PhIO and NaClO. Our results showed that the use of T(p-NO2)PPFeCl with PhI(OAc)2 as the oxidant in the presence of water displays remarkable activity for the desired oxidation reaction. The generality of this method was examined by synthesizing the carboxylic acids of pyridines and quinolines.

Palladium-catalyzed aminocarbonylation of heteroaryl halides using di-tert-butylphosphinoferrocene

Pd-catalyzed aminocarbonylation of heteroaryl halides, using monodentate ligand di-tert-butylphosphinoferrocene tetrafluoroborate is reported. Good to high yields were obtained with chiral amines on a variety of substrates including 2-bromo heteroaryls.

CATALYSTS COMPRISING N-SUBSTITUTED CYCLIC IMIDES AND PROCESSES FOR PREPARING ORGANIC COMPOUNDS WITH THE CATALYSTS

A catalyst of the invention includes an imide compound having a N-substituted cyclic imide skeleton represented by following Formula (I): wherein R is a hydroxyl-protecting group. Preferred R is a hydrolyzable protecting group. R may be a group obtained from an acid by eliminating an OH group therefrom. Such acids include, for example, carboxylic acids, sulfonic acids, carbonic acid, carbamic acid, sulfuric acid, nitric acid, phosphoric acids and boric acids. The catalyst may include the imide compound and a metallic compound in combination. In the presence of the catalyst, (A) a compound capable of forming a radical is allowed to react with (B) a radical scavenging compound and thereby yields an addition or substitution reaction product of the compound (A) and the compound (B) or a derivative thereof. This catalyst can produce an organic compound with a high selectivity in a high yield as a result of, for example, an addition or substitution reaction under mild conditions.