1200497-81-9

Basic information

• Product Name: 2-Carboxy-3-chloro-5-cyanopyridine, 6-Carboxy-5-chloropyridine-3-carbonitrile, 3-Chloro-5-cyanopicolinic acid
• Synonyms: 2-Carboxy-3-chloro-5-cyanopyridine, 6-Carboxy-5-chloropyridine-3-carbonitrile, 3-Chloro-5-cyanopicolinic acid;3-Chloro-5-cyanopyridine-2-carboxylic acid;3-chloro-5-cyanopicolinic acid
• CAS NO: 1200497-81-9
• Molecular Formula: C₇H₃ClN₂O₂
• Molecular Weight: 529.67648
• Mol File: 1200497-81-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Carboxy-3-chloro-5-cyanopyridine, 6-Carboxy-5-chloropyridine-3-carbonitrile, 3-Chloro-5-cyanopicolinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Carboxy-3-chloro-5-cyanopyridine, 6-Carboxy-5-chloropyridine-3-carbonitrile, 3-Chloro-5-cyanopicolinic acid(1200497-81-9)
• EPA Substance Registry System: 2-Carboxy-3-chloro-5-cyanopyridine, 6-Carboxy-5-chloropyridine-3-carbonitrile, 3-Chloro-5-cyanopicolinic acid(1200497-81-9)

Safety Data

• Hazardous Substances Data: 1200497-81-9(Hazardous Substances Data)

Upstream product

• 1620981-12-5 tert-butyl 3-chloro-5-cyanopicolinate 
• 1335056-20-6 tert-butyl 5-bromo-3-chloropicolinate 
• 1189513-51-6 5-bromo-3-chloro-pyridine-2-carboxylic acid 
• 1200497-79-5 C₇H₅ClN₂O₃ 
• 1200497-77-3 C₉H₈ClNO₄ 
• 127140-59-4 5-ethoxycarbonylpicolinic acid N-oxide 
• 127140-57-2 2,5-di(ethoxycarbonyl)pyridine N-oxide 
• 5552-44-3 ethyl 2,5-pyridinedicarboxylate 

Downstream Products

• 1200494-62-7 (S)-N-(3-(2-amino-4-methyl-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide 
• 1374651-85-0 methyl 3-chloro-5-cyanopicolinate 
• 1404322-77-5 (S)-N-(3-(2-amino-6-(fluoromethyl)-4-methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide 
• 1352417-16-3 N-{3-[(2R,3R)-5-amino-2-fluoro-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-3-chloro-5-cyanopyridine-2-carboxamide 
• 1352418-12-2 N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-3-chloro-5-cyanopyridine-2-carboxamide 
• 1448793-21-2 N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyano-2-pyridinecarboxamide 
• 1624604-67-6 N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-3-chloro-5-cyanopicolinamide 
• 1386985-76-7 ((2R,5R)-5-{5-[(3-chloro-5-cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-2,5-dimethyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester 

Relevant articles and documents

FUSED MULTI-CYCLIC SULFONE COMPOUNDS AS INHIBITORS OF BETA-SECRETASE AND METHODS OF USE THEREOF

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A5, A6, A8, R1, R2, R3, R7, X, Y, n and o of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, compounds of Formula III, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III, and sub-Formulas thereof.