C₂₂H₂₄FN₅O₃

Base Information

Chemical Name:C₂₂H₂₄FN₅O₃
CAS No.:1353623-02-5
Molecular Formula:C₂₂H₂₄FN₅O₃
Molecular Weight:425.463
Hs Code.:

C<sub>22</sub>H<sub>24</sub>FN<sub>5</sub>O<sub>3</sub>

Synonyms:C₂₂H₂₄FN₅O₃

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Chemical Property of C₂₂H₂₄FN₅O₃

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Technology Process of C₂₂H₂₄FN₅O₃

There total 6 articles about C₂₂H₂₄FN₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: (S)-5,6-dimethyl-2-(piperidin-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one dihydrochloride

: 49579-56-8
2-acetamido-5-fluorobenzoic acid

: 1353623-02-5
C₂₂H₂₄FN₅O₃

Guidance literature:: 2-acetamido-5-fluorobenzoic acid; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

(S)-5,6-dimethyl-2-(piperidin-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one dihydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield:

: 203056-27-3
tert-butyl (2S)-2-{[methoxy(methyl)amino]-carbonyl}piperidine-1-carboxylate

: 1353623-02-5
C₂₂H₂₄FN₅O₃

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.42 h / -78 - -20 °C / Inert atmosphere

1.2: 3.08 h / -78 - -45 °C

1.3: -78 - 20 °C

2.1: hydrazinium monoacetate / ethanol / 16 h / 20 °C

3.1: acetic acid / 0.75 h / 100 °C

4.1: hydrogenchloride / 1,4-dioxane / 65 h

5.1: HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

5.2: 5 h / 20 °C

With hydrogenchloride; sodium bis(trimethylsilyl)amide; hydrazinium monoacetate; acetic acid; HATU; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 200184-53-8
(S)-1-tert-butyl 2-methyl piperidine-1,2-dicarboxylate

: 1353623-02-5
C₂₂H₂₄FN₅O₃

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran; hexanes / -78 - -40 °C

1.2: -78 - -40 °C

1.3: -78 - 20 °C

2.1: hydrazinium monoacetate / ethanol / 16 h / 20 °C

3.1: acetic acid / 0.75 h / 100 °C

4.1: hydrogenchloride / 1,4-dioxane / 65 h

5.1: HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

5.2: 5 h / 20 °C

With hydrogenchloride; sodium bis(trimethylsilyl)amide; hydrazinium monoacetate; acetic acid; HATU; In tetrahydrofuran; 1,4-dioxane; hexanes; ethanol; N,N-dimethyl-formamide;