49579-56-8

Usage

Uses

Used in Pharmaceutical Industry:
2-ACETAMIDO-5-FLUOROBENZOIC ACID is utilized as a key intermediate in the synthesis of a range of pharmaceuticals, primarily for the production of anti-inflammatory and analgesic drugs. Its unique chemical structure allows it to serve as a building block in the creation of medications that address pain and inflammation.
Given its potential health hazards, 2-ACETAMIDO-5-FLUOROBENZOIC ACID is subject to regulations for safe handling and storage to ensure the well-being of those who work with it in the pharmaceutical sector.

InChI:InChI=1/C9H8FNO3/c1-5(12)11-8-3-2-6(10)4-7(8)9(13)14/h2-4H,1H3,(H,11,12)(H,13,14)

Upstream product

• 446-08-2 2-amino-5-fluorobenzoic acid 
• 32833-96-8 N,N-dimethyloxamic acid 
• 351-83-7 4'-fluoroacetanilide 
• 326-65-8 N-(4-fluoro-2-methylphenyl)acetamide 

Downstream Products

• 446-08-2 2-amino-5-fluorobenzoic acid 
• 291276-26-1 3-(2-chloro-phenyl)-6-fluoro-2-[2-(2-fluoro-phenyl)-2-hydroxy-vinyl]-3H-quinazolin-4-one 
• 1353623-02-5 C₂₂H₂₄FN₅O₃ 
• 52548-63-7 5-fluoro-2-iodobenzoic acid 
• 56096-98-1 [2-(4-Chloro-phenylsulfanyl)-5-fluoro-phenyl]-acetic acid 
• 56096-96-9 [2-(4-Chloro-phenylsulfanyl)-5-fluoro-phenyl]-acetonitrile 
• 56096-90-3 2-(4-Chlorphenylthio)-5-fluorbenzoesaeure 
• 56096-94-7 2-(4-Chlorphenylthio)-5-fluorbenzylchlorid 
• 56096-92-5 2-(4-Chlorphenylthio)-5-fluorbenzylalkohol 
• 49579-12-6 3-(2-chloro-phenyl)-6-fluoro-2-methyl-3H-quinazolin-4-one 

Relevant academic research and scientific papers

De Novo Biosynthesis and Whole-Cell Catalytic Production of 2-Acetamidophenol in Escherichia coli

2-Acetamidophenol (AAP) is an aromatic product with promising activities in agricultural applications and medical research. At present, AAP is synthesized by chemical methods from nonrenewable fossil fuel resources, which cause environmental pollution and the reaction conditions are harsh. In this study, we constructed the artificial biosynthetic pathway of AAP with five different expressed proteins in Escherichia coli for the first time. By introducing the hydrogen peroxide degrading enzyme catalase and improving cell tolerance to toxic intermediates or products, the yield of AAP reached 33.54 mg/L using shaking-flask culture. The best-engineered strain could produce 568.57 mg/L AAP by fed-batch fermentation from glucose and precursor (2-aminophenol, 2-AP) addition. Furthermore, a one-pot whole-cell cascade biocatalytic pathway to AAP and analogues was developed and optimized. This method can efficiently produce 1.8 g/L AAP using the methyl anthranilate hydrolysis product as the substrate. This study provides not only the de novo artificial biosynthetic pathway of AAP in E. coli but also a promising sustainable and efficient strategy to enable the synthesis of AAP on a gram scale.

Palladium-catalyzed C-H bond carboxylation of acetanilides: An efficient usage of N,N-dimethyloxamic acid as the carboxylate source

N,N-Dimethyloxamic acid can be successfully employed as a carboxylate precursor in the palladium-catalyzed direct C-H carboxylation of acetanilides. The reaction proceeds smoothly under mild conditions over a broad range of substrates with high functional group tolerance, affording substituted N-acyl anthranilic acids in moderate to high yields.

Amino-benzoic acids and derivatives, and methods of use

The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.