(S)-3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropyl (2,5-dioxopyrrolidin-1-yl) succinate

Base Information

• Chemical Name: (S)-3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropyl (2,5-dioxopyrrolidin-1-yl) succinate
• CAS No.: 1596369-20-8
• Molecular Formula: C₂₄H₂₁F₃IN₃O₉
• Molecular Weight: 679.345

Synonyms:(S)-3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropyl (2,5-dioxopyrrolidin-1-yl) succinate

Chemical Property of (S)-3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropyl (2,5-dioxopyrrolidin-1-yl) succinate

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Technology Process of (S)-3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropyl (2,5-dioxopyrrolidin-1-yl) succinate

There total 2 articles about (S)-3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropyl (2,5-dioxopyrrolidin-1-yl) succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + (S)-4-(3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropoxy)-4-oxobutanoic acid (1596369-19-5) → (S)-3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropyl (2,5-dioxopyrrolidin-1-yl) succinate (1596369-20-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.3390/molecules181113957

Reference yield:

N-[(S)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide (391209-97-5) → (S)-3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropyl (2,5-dioxopyrrolidin-1-yl) succinate (1596369-20-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1 h / 20 °C

2: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 24 h / 20 °C

With pyridine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.3390/molecules181113957

Reference yield: 40.0%

(S)-3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropyl (2,5-dioxopyrrolidin-1-yl) succinate (1596369-20-8) + [(2S,5R,8S,11S)-8-(4-Amino-butyl)-11-(3-guanidino-propyl)-5-(4-hydroxy-benzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid (217099-14-4) → C47H58F3IN12O13

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; pH=8.5-9; Time;

DOI:10.3390/molecules181113957

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

(S)-4-(3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropoxy)-4-oxobutanoic acid

N-[(S)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide

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