(S)-4-(3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropoxy)-4-oxobutanoic acid

Base Information

Chemical Name:(S)-4-(3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropoxy)-4-oxobutanoic acid
CAS No.:1596369-19-5
Molecular Formula:C₂₀H₁₈F₃IN₂O₇
Molecular Weight:582.272
Hs Code.:

Synonyms:(S)-4-(3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropoxy)-4-oxobutanoic acid

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Chemical Property of (S)-4-(3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropoxy)-4-oxobutanoic acid

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Technology Process of (S)-4-(3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropoxy)-4-oxobutanoic acid

There total 1 articles about (S)-4-(3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropoxy)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 108-30-5
succinic acid anhydride

: 391209-97-5
N-[(S)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide

: 1596369-19-5
(S)-4-(3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropoxy)-4-oxobutanoic acid

Guidance literature:: With pyridine; at 20 ℃; for 1h;
DOI:10.3390/molecules181113957

Reference yield: 35.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 1596369-19-5
(S)-4-(3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropoxy)-4-oxobutanoic acid

: 1596369-20-8
(S)-3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropyl (2,5-dioxopyrrolidin-1-yl) succinate

Guidance literature:: With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.3390/molecules181113957

Reference yield:

: 1596369-19-5
(S)-4-(3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)-2-hydroxypropoxy)-4-oxobutanoic acid

: C₄₇H₅₈F₃IN₁₂O₁₃

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 24 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / pH 8.5-9

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.3390/molecules181113957