[2R(4R,5R,6S)]-2-[6-(2-benzyloxyethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-N-methoxy-N-methylpropionamide

Base Information

Chemical Name:[2R(4R,5R,6S)]-2-[6-(2-benzyloxyethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-N-methoxy-N-methylpropionamide
CAS No.:475232-95-2
Molecular Formula:C₂₁H₃₃NO₅
Molecular Weight:379.497
Hs Code.:

Synonyms:[2R(4R,5R,6S)]-2-[6-(2-benzyloxyethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-N-methoxy-N-methylpropionamide

Suppliers and Price of [2R(4R,5R,6S)]-2-[6-(2-benzyloxyethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-N-methoxy-N-methylpropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2R(4R,5R,6S)]-2-[6-(2-benzyloxyethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-N-methoxy-N-methylpropionamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [2R(4R,5R,6S)]-2-[6-(2-benzyloxyethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-N-methoxy-N-methylpropionamide

There total 4 articles about [2R(4R,5R,6S)]-2-[6-(2-benzyloxyethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-N-methoxy-N-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 77-76-9
2,2-dimethoxy-propane

: 475232-94-1
(2R,3R,4R,5S)-7-benzyloxy-3,5-dihydroxy-2,4-dimethylheptanoic acid methoxy-methyl-amide

: 475232-95-2
[2R(4R,5R,6S)]-2-[6-(2-benzyloxyethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-N-methoxy-N-methylpropionamide

Guidance literature:: With toluene-4-sulfonic acid; In acetone; at 20 ℃; for 0.5h;
DOI:10.1016/S0040-4020(02)00723-8

Reference yield:

: 19790-60-4
3-Benzyloxypropanal

: 475232-95-2
[2R(4R,5R,6S)]-2-[6-(2-benzyloxyethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-N-methoxy-N-methylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.33 h / -78 °C

1.2: tetrahydrofuran; hexane / -78 °C

1.3: 57 percent / tetrahydrofuran; hexane / 0.67 h / -78 °C

2.1: 69 percent / NaBH(OAc)3 / acetic acid / 0.75 h / 20 °C

3.1: 86 percent / p-toluenesulfonic acid / acetone / 0.5 h / 20 °C

With n-butyllithium; sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; acetic acid; acetone;
DOI:10.1016/S0040-4020(02)00723-8

Reference yield:

: 476365-25-0
methylketene dimer

: 475232-95-2
[2R(4R,5R,6S)]-2-[6-(2-benzyloxyethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-N-methoxy-N-methylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.33 h / -78 °C

1.2: tetrahydrofuran; hexane / -78 °C

1.3: 57 percent / tetrahydrofuran; hexane / 0.67 h / -78 °C

2.1: 69 percent / NaBH(OAc)3 / acetic acid / 0.75 h / 20 °C

3.1: 86 percent / p-toluenesulfonic acid / acetone / 0.5 h / 20 °C

With n-butyllithium; sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; acetic acid; acetone;
DOI:10.1016/S0040-4020(02)00723-8