(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 3-oxobutanoate

Base Information

Chemical Name:(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 3-oxobutanoate
CAS No.:1215080-62-8
Molecular Formula:C₁₈H₂₄O₅S
Molecular Weight:352.452
Hs Code.:

Synonyms:(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 3-oxobutanoate

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Chemical Property of (2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 3-oxobutanoate

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Technology Process of (2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 3-oxobutanoate

There total 3 articles about (2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 674-82-8,2130-41-8
4-methyleneoxetan-2-one

: 1215080-61-7
(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-ol

: 1215080-62-8
(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 3-oxobutanoate

Guidance literature:: With pyridine; In acetone; for 4h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2011.10.025

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1215080-62-8
(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 3-oxobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

2.3: 20 °C / Inert atmosphere

3.1: pyridine / acetone / 4 h / Inert atmosphere; Reflux

With pyridine; pyridinium p-toluenesulfonate; sodium hydride; In tetrahydrofuran; dichloromethane; acetone; mineral oil;
DOI:10.1016/j.tet.2011.10.025

Reference yield:

: 110657-96-0
2-((R)-oxiran-2-ylmethoxy)tetrahydro-2H-pyran

: 1215080-62-8
(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 3-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: pyridine / acetone / 4 h / Inert atmosphere; Reflux

With pyridine; sodium hydride; In tetrahydrofuran; acetone; mineral oil;
DOI:10.1016/j.tet.2011.10.025