(4S)-3-ethyl 5-(1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Name:(4S)-3-ethyl 5-(1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:1215080-64-0
Molecular Formula:C₃₁H₃₅Cl₂NO₆S
Molecular Weight:620.594
Hs Code.:

Synonyms:(4S)-3-ethyl 5-(1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Property of (4S)-3-ethyl 5-(1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of (4S)-3-ethyl 5-(1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 5 articles about (4S)-3-ethyl 5-(1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1215080-63-9
(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate

: 626-34-6
ethyl 3-aminobut-2-enoate

: 1215080-64-0
(4S)-3-ethyl 5-(1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With pyridine; for 4h; Reflux;
DOI:10.1016/j.tet.2011.10.025

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1215080-64-0
(4S)-3-ethyl 5-(1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

2.3: 20 °C / Inert atmosphere

3.1: pyridine / acetone / 4 h / Inert atmosphere; Reflux

4.1: piperidine; acetic acid / benzene / 2 h / Inert atmosphere; Reflux

5.1: pyridine / 4 h / Reflux

With piperidine; pyridine; pyridinium p-toluenesulfonate; sodium hydride; acetic acid; In tetrahydrofuran; dichloromethane; acetone; mineral oil; benzene; 4.1: Knoevenagel reaction / 5.1: Hantzsch dihydropyridine synthesis;
DOI:10.1016/j.tet.2011.10.025

Reference yield:

: 1215080-61-7
(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-ol

: 1215080-64-0
(4S)-3-ethyl 5-(1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / acetone / 4 h / Inert atmosphere; Reflux

2: piperidine; acetic acid / benzene / 2 h / Inert atmosphere; Reflux

3: pyridine / 4 h / Reflux

With piperidine; pyridine; acetic acid; In acetone; benzene; 2: Knoevenagel reaction / 3: Hantzsch dihydropyridine synthesis;
DOI:10.1016/j.tet.2011.10.025