2-(3-chlorophenyl)-N,N-dimethyl-2-oxo-acetamide

Base Information

• Chemical Name: 2-(3-chlorophenyl)-N,N-dimethyl-2-oxo-acetamide
• CAS No.: 1628191-38-7
• Molecular Formula: C₁₀H₁₀ClNO₂
• Molecular Weight: 211.648
• Mol file: 1628191-38-7.mol

Synonyms:2-(3-chlorophenyl)-N,N-dimethyl-2-oxo-acetamide

Chemical Property of 2-(3-chlorophenyl)-N,N-dimethyl-2-oxo-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-chlorophenyl)-N,N-dimethyl-2-oxo-acetamide

There total 4 articles about 2-(3-chlorophenyl)-N,N-dimethyl-2-oxo-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-chlorophenylacetic acid (1878-65-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(3-chlorophenyl)-N,N-dimethyl-2-oxo-acetamide (1628191-38-7)

Guidance literature:

With copper(I) oxide; 1,10-Phenanthroline; di-tert-butyl peroxide; Trimethylacetic acid; at 130 ℃; for 24h; Schlenk technique;

DOI:10.1080/00397911.2015.1049273

Reference yield: 69.0%

1-chloro-3-methylbenzene (108-41-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(3-chlorophenyl)-N,N-dimethyl-2-oxo-acetamide (1628191-38-7)

Guidance literature:

With di-tert-butyl peroxide; tetra-(n-butyl)ammonium iodide; caesium carbonate; at 120 ℃; for 12h;

DOI:10.1016/j.tetlet.2015.06.021

Reference yield: 67.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 3'-Chloroacetophenone (99-02-5) → 2-(3-chlorophenyl)-N,N-dimethyl-2-oxo-acetamide (1628191-38-7)

Guidance literature:

With copper(I) oxide; oxygen; acetic acid; at 100 ℃; for 24h;

DOI:10.1055/s-0033-1339109

upstream raw materials:

N,N-dimethyl-formamide

3'-Chloroacetophenone

3-chlorophenylacetic acid

1-chloro-3-methylbenzene