Cbz-L-tBuGlyΨ-L-Phe-OMe

Base Information

Chemical Name:Cbz-L-tBuGlyΨ-L-Phe-OMe
CAS No.:214286-94-9
Molecular Formula:C₂₅H₃₁NO₅
Molecular Weight:425.525
Hs Code.:

Synonyms:Cbz-L-tBuGlyΨ-L-Phe-OMe

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cbz-L-tBuGlyΨ-L-Phe-OMe

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Technology Process of Cbz-L-tBuGlyΨ-L-Phe-OMe

There total 7 articles about Cbz-L-tBuGlyΨ-L-Phe-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025794-09-5
(R)-2-Benzyl-3-((S)-2-benzyloxycarbonylamino-3,3-dimethyl-butyryl)-succinic acid 4-tert-butyl ester 1-methyl ester

: 214286-94-9
Cbz-L-tBuGlyΨ-L-Phe-OMe

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 24h; Yield given;
DOI:10.1021/jm980537b

Reference yield:

: 20859-02-3
L-tert-Leucine

: 214286-94-9
Cbz-L-tBuGlyΨ-L-Phe-OMe

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / 1.0 M aq. NaOH / dioxane / 18 h / 0 °C

2: 1.) LDA, 2.) 1,1'-carbonyldiimidazole / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, -78 deg C, 1 h

3: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₂Cl₂, 23 deg C, 24 h

4: TFA / CH₂Cl₂ / 24 h / 23 °C

With sodium hydroxide; sodium hydride; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium diisopropyl amide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm980537b

Reference yield:

: 62965-10-0
(S)-N-carbobenzoxy-tert-butylleucine

: 214286-94-9
Cbz-L-tBuGlyΨ-L-Phe-OMe

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA, 2.) 1,1'-carbonyldiimidazole / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, -78 deg C, 1 h

2: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₂Cl₂, 23 deg C, 24 h

3: TFA / CH₂Cl₂ / 24 h / 23 °C

With sodium hydride; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jm980537b