N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-4-methylpyrimidine-5-carboxamide

Base Information

Chemical Name:N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-4-methylpyrimidine-5-carboxamide
CAS No.:1288342-30-2
Molecular Formula:C₁₉H₁₄F₅N₅O
Molecular Weight:423.345
Hs Code.:

Synonyms:N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-4-methylpyrimidine-5-carboxamide

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Chemical Property of N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-4-methylpyrimidine-5-carboxamide

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Technology Process of N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-4-methylpyrimidine-5-carboxamide

There total 6 articles about N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-4-methylpyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1288342-32-4
N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-2-[(dimethylamino)methylene]-3-oxobutanamide

: 3473-63-0
formamidine acetic acid

: 1288342-30-2
N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-4-methylpyrimidine-5-carboxamide

Guidance literature:: With sodium ethanolate; In ethanol; for 3h; Reflux;

Reference yield:

: 1062295-85-5,1027617-86-2
3-cyclopropyl-5-(trifluoromethyl)-1H-pyrazole

: 1288342-30-2
N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-4-methylpyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran / 2 h / Reflux

2: ammonium chloride; iron / ethanol; water / 1 h / Reflux

3: xylene / 1.5 h / 145 °C

4: 25 - 28 °C

5: sodium ethanolate / ethanol / 3 h / Reflux

With sodium ethanolate; iron; sodium hydride; ammonium chloride; In tetrahydrofuran; ethanol; water; xylene;

Reference yield:

: 30923-69-4
1‐cyclopropyl‐4,4,4‐trifluorobutane‐1,3‐dione

: 1288342-30-2
N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-4-methylpyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrazine hydrate / ethanol / Reflux

2: sodium hydride / tetrahydrofuran / 2 h / Reflux

3: ammonium chloride; iron / ethanol; water / 1 h / Reflux

4: xylene / 1.5 h / 145 °C

5: 25 - 28 °C

6: sodium ethanolate / ethanol / 3 h / Reflux

With sodium ethanolate; iron; sodium hydride; ammonium chloride; hydrazine hydrate; In tetrahydrofuran; ethanol; water; xylene;