3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid ethyl ester

Base Information

Chemical Name:3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid ethyl ester
CAS No.:1300022-24-5
Molecular Formula:C₁₆H₁₃FN₂O₂
Molecular Weight:284.29
Hs Code.:

Synonyms:3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid ethyl ester

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Chemical Property of 3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid ethyl ester

There total 4 articles about 3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38749-79-0
3-bromo-2-picoline

: 1300022-24-5
3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 31 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 24 h / Reflux

3.1: trichlorophosphate / Reflux

3.2: Cooling with ice

4.1: triethylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 140 °C / 11251.1 Torr

With N-Bromosuccinimide; sodium hydride; triethylamine; trichlorophosphate; dibenzoyl peroxide; 1,1'-bis-(diphenylphosphino)ferrocene; bis(benzonitrile)palladium(II) dichloride; In tetrahydrofuran; tetrachloromethane; mineral oil;

Reference yield:

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 1300022-22-3
8-bromo-3-(4-fluorophenyl)-imidazo[1,5-a]pyridine

: 1300022-24-5
3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid ethyl ester

Guidance literature:: With triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; bis(benzonitrile)palladium(II) dichloride; at 140 ℃; for 4h; under 11251.1 Torr;

Reference yield:

: 754131-60-7
3-bromo-2-(bromomethyl)pyridine

: 1300022-24-5
3-(4-fluorophenyl)-imidazo[1,5-a]pyridine-8-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 24 h / Reflux

2.1: trichlorophosphate / Reflux

2.2: Cooling with ice

3.1: triethylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 140 °C / 11251.1 Torr

With sodium hydride; triethylamine; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; bis(benzonitrile)palladium(II) dichloride; In tetrahydrofuran; mineral oil;