dimethylsulfonium 1-(phenylacetyl)-2-oxo-3-(pentafluorohenyl)propylide

Base Information

• Chemical Name: dimethylsulfonium 1-(phenylacetyl)-2-oxo-3-(pentafluorohenyl)propylide
• CAS No.: 161152-05-2
• Molecular Formula: C₁₉H₁₅F₅O₂S
• Molecular Weight: 402.385
• Mol file: 161152-05-2.mol

Synonyms:dimethylsulfonium 1-(phenylacetyl)-2-oxo-3-(pentafluorohenyl)propylide

Chemical Property of dimethylsulfonium 1-(phenylacetyl)-2-oxo-3-(pentafluorohenyl)propylide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethylsulfonium 1-(phenylacetyl)-2-oxo-3-(pentafluorohenyl)propylide

There total 6 articles about dimethylsulfonium 1-(phenylacetyl)-2-oxo-3-(pentafluorohenyl)propylide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-dimethylsulfoniumsuccinimide chloride (39095-38-0) + 1-phenyl-5-(pentafluorophenyl)-4-hydroxy-2-pentanone (161152-01-8) → dimethylsulfonium 1-(phenylacetyl)-2-oxo-3-(pentafluorohenyl)propylide (161152-05-2)

Guidance literature:

With N-chloro-succinimide; triethylamine; In dichloromethane; at -70 ℃; for 2h;

DOI:10.1021/jo960887a

Reference yield:

1-allyl-2,3,4,5,6-pentafluorobenzene (1736-60-3) → dimethylsulfonium 1-(phenylacetyl)-2-oxo-3-(pentafluorohenyl)propylide (161152-05-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / 5percent NaOCl, Py / CHCl₃ / 1.5 h / 0 °C

2: 88 percent / H₂, AcOH, H₂O / Raney Ni / tetrahydrofuran / Ambient temperature

3: 92 percent / NCS, Et₃N / CH₂Cl₂ / 2 h / -70 °C

With pyridine; sodium hypochlorite; N-chloro-succinimide; water; hydrogen; acetic acid; triethylamine; nickel; In tetrahydrofuran; dichloromethane; chloroform;

DOI:10.1021/jo960887a

Reference yield:

3-benzyl-5-<(pentafluorophenyl)methyl>-2-isoxazoline (161151-99-1) → dimethylsulfonium 1-(phenylacetyl)-2-oxo-3-(pentafluorohenyl)propylide (161152-05-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / H₂, AcOH, H₂O / Raney Ni / tetrahydrofuran / Ambient temperature

2: 92 percent / NCS, Et₃N / CH₂Cl₂ / 2 h / -70 °C

With N-chloro-succinimide; water; hydrogen; acetic acid; triethylamine; nickel; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo960887a

upstream raw materials:

N-chlorosuccinimide-dimethylsulfide complex

1-phenyl-5-(pentafluorophenyl)-4-hydroxy-2-pentanone

N-dimethylsulfoniumsuccinimide chloride

1-allyl-2,3,4,5,6-pentafluorobenzene