Corey-Kim reagent

Base Information

• Chemical Name: Corey-Kim reagent
• CAS No.: 39095-38-0
• Molecular Formula: C6H10ClNO2S
• Molecular Weight: 195.67
• Hs Code.: 2930909090
• Mol file: 39095-38-0.mol

Synonyms:dimethyl succinimidylsulfonium chloride;succinimide-dimethylsulfonium chloride;N-dimethylsulfoniumsuccinimide chloride;dimethyl-succinimido-sulfonium,chloride;Corey-Kim reagent;N-CHLOROSUCCINIMIDE-DIMETHYL SULFIDE;Corey-Kim regent;

Chemical Property of Corey-Kim reagent

Chemical Property:

• PSA: 62.68000
• LogP: 1.20630
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 195.0120774
• Heavy Atom Count: 11
• Complexity: 163

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C[S+](C)N1C(=O)CCC1=O.[Cl-]

Technology Process of Corey-Kim reagent

There total 2 articles about Corey-Kim reagent which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-chloro-succinimide (128-09-6) + dimethylsulfide (75-18-3) → N-dimethylsulfoniumsuccinimide chloride (39095-38-0)

Guidance literature:

In dichloromethane; at -40 - -30 ℃; for 1h;

DOI:10.1021/jo00348a014

Reference yield:

→ N-dimethylsulfoniumsuccinimide chloride (39095-38-0)

Guidance literature:

Reference yield: 99.0%

N-dimethylsulfoniumsuccinimide chloride (39095-38-0) + 1,3-diphenylpropanedione (120-46-7,61346-73-4) → 2-(dimethyl-λ4-sulfaneylidene)-1,3-diphenylpropane-1,3-dione (34025-26-8)

Guidance literature:

With triethylamine; In dichloromethane; at -78 ℃; for 1h; various methylene compounds;

DOI:10.1248/cpb.38.3314

upstream raw materials:

N-chloro-succinimide

dimethylsulfide

Downstream raw materials:

chloro-methylsulfanyl-methane

N-benzyl-S,S-dimethylsulfilimmonium chloride

Succinimide

O-Methyl-thioethyl-succinimid