N-(6-(2-(methoxymethyl)pyrrolidin-1-yl)pyridin-2-yl)-6-phenylimidazo[1,2-b]pyridazin-8-amine hydrochloride

Base Information

Chemical Name:N-(6-(2-(methoxymethyl)pyrrolidin-1-yl)pyridin-2-yl)-6-phenylimidazo[1,2-b]pyridazin-8-amine hydrochloride
CAS No.:1431772-85-8
Molecular Formula:C₂₃H₂₄N₆O*ClH
Molecular Weight:436.944
Hs Code.:

Synonyms:N-(6-(2-(methoxymethyl)pyrrolidin-1-yl)pyridin-2-yl)-6-phenylimidazo[1,2-b]pyridazin-8-amine hydrochloride

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Chemical Property of N-(6-(2-(methoxymethyl)pyrrolidin-1-yl)pyridin-2-yl)-6-phenylimidazo[1,2-b]pyridazin-8-amine hydrochloride

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Technology Process of N-(6-(2-(methoxymethyl)pyrrolidin-1-yl)pyridin-2-yl)-6-phenylimidazo[1,2-b]pyridazin-8-amine hydrochloride

There total 6 articles about N-(6-(2-(methoxymethyl)pyrrolidin-1-yl)pyridin-2-yl)-6-phenylimidazo[1,2-b]pyridazin-8-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1431773-73-7
8-bromo-6-phenylimidazo[1,2-b]pyridazine

: 1431773-91-9
6-(2-(methoxymethyl)pyrrolidin-1-yl)pyridin-2-amine

: 1431772-85-8
N-(6-(2-(methoxymethyl)pyrrolidin-1-yl)pyridin-2-yl)-6-phenylimidazo[1,2-b]pyridazin-8-amine hydrochloride

Guidance literature:: 8-bromo-6-phenylimidazo[1,2-b]pyridazine; 6-(2-(methoxymethyl)pyrrolidin-1-yl)pyridin-2-amine; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 100 ℃; for 16h; Inert atmosphere; Sealed tube;

With hydrogenchloride; In water; acetonitrile;

Reference yield:

: 1597-32-6
6-fluoro-pyridin-2-ylamine

: 1431772-85-8
N-(6-(2-(methoxymethyl)pyrrolidin-1-yl)pyridin-2-yl)-6-phenylimidazo[1,2-b]pyridazin-8-amine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: water / 0.5 h / 205 °C / Microwave irradiation; Sealed tube

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; water;

Reference yield:

: 98-80-6
phenylboronic acid

: 1431772-85-8
N-(6-(2-(methoxymethyl)pyrrolidin-1-yl)pyridin-2-yl)-6-phenylimidazo[1,2-b]pyridazin-8-amine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium carbonate / water; 1,4-dioxane / 6 h / 100 °C / Inert atmosphere

2: bromine; sodium hydrogencarbonate / methanol / 16.5 h / 20 °C

3: toluene-4-sulfonic acid / isopropyl alcohol / 40 h / 80 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; sodium hydrogencarbonate; sodium carbonate; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; XPhos; In 1,4-dioxane; methanol; water; isopropyl alcohol;