(S)-5-(aminoniethyl)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)oxazolidin-2-one

Base Information

Chemical Name:(S)-5-(aminoniethyl)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)oxazolidin-2-one
CAS No.:1430321-44-0
Molecular Formula:C₁₆H₂₄FN₃O₂Si
Molecular Weight:337.469
Hs Code.:

Synonyms:(S)-5-(aminoniethyl)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)oxazolidin-2-one

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Chemical Property of (S)-5-(aminoniethyl)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)oxazolidin-2-one

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Technology Process of (S)-5-(aminoniethyl)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)oxazolidin-2-one

There total 10 articles about (S)-5-(aminoniethyl)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 415684-05-8
tert-butyl (2S)-3-chloro-2-hydroxypropylcarbamate

: 1430321-43-9
benzyl 4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenylcarbamate

: 1430321-44-0
(S)-5-(aminoniethyl)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)oxazolidin-2-one

Guidance literature:: tert-butyl (2S)-3-chloro-2-hydroxypropylcarbamate; benzyl 4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenylcarbamate; With lithium tert-butoxide; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 45h;

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 3h;

Reference yield:

: C₂₁H₃₂FN₃O₄Si

: 1430321-44-0
(S)-5-(aminoniethyl)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)oxazolidin-2-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 3h;

Reference yield:

: 1430321-42-8
1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane

: 1430321-44-0
(S)-5-(aminoniethyl)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 8 h / 1810.07 Torr

2: sodium hydrogencarbonate / tetrahydrofuran / 5 h / 0 - 25 °C

3: lithium tert-butoxide / N,N-dimethyl-formamide / 45 h / 0 - 25 °C

4: trifluoroacetic acid / dichloromethane / 3 h / 25 °C

With palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; lithium tert-butoxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;