(S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Base Information

Chemical Name:(S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
CAS No.:1430321-45-1
Molecular Formula:C₁₈H₂₆FN₃O₃Si
Molecular Weight:379.507
Hs Code.:

Synonyms:(S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

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Chemical Property of (S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

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Technology Process of (S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

There total 12 articles about (S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1430321-44-0
(S)-5-(aminoniethyl)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)oxazolidin-2-one

: 75-36-5
acetyl chloride

: 1430321-45-1
(S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.5b00213

Reference yield:

: 1430321-43-9
benzyl 4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenylcarbamate

: (S)-N-(2-(chloromethyl)-4-oxopentyl)acetamide

: 1430321-45-1
(S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Guidance literature:: benzyl 4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenylcarbamate; With lithium tert-butoxide; In N,N-dimethyl-formamide; at 25 ℃; for 0.25h;

(S)-N-(2-(chloromethyl)-4-oxopentyl)acetamide; With methanol; In N,N-dimethyl-formamide; at 25 ℃; for 24h;

Reference yield:

: 1430321-43-9
benzyl 4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenylcarbamate

: 183905-31-9
N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

: 1430321-45-1
(S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Guidance literature:: benzyl 4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenylcarbamate; With lithium tert-butoxide; In N,N-dimethyl-formamide; at 25 ℃; for 0.25h;

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide; In methanol; N,N-dimethyl-formamide; at 25 ℃; for 24h;