(R)-(3-(5-(1-(quinuclidin-3-yl)-1H-1,2,3-triazol-4-yl)thiophen-2-yl)phenyl)methanol

Base Information

Chemical Name:(R)-(3-(5-(1-(quinuclidin-3-yl)-1H-1,2,3-triazol-4-yl)thiophen-2-yl)phenyl)methanol
CAS No.:1404051-40-6
Molecular Formula:C₂₀H₂₂N₄OS
Molecular Weight:366.487
Hs Code.:

Synonyms:(R)-(3-(5-(1-(quinuclidin-3-yl)-1H-1,2,3-triazol-4-yl)thiophen-2-yl)phenyl)methanol

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Chemical Property of (R)-(3-(5-(1-(quinuclidin-3-yl)-1H-1,2,3-triazol-4-yl)thiophen-2-yl)phenyl)methanol

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Technology Process of (R)-(3-(5-(1-(quinuclidin-3-yl)-1H-1,2,3-triazol-4-yl)thiophen-2-yl)phenyl)methanol

There total 4 articles about (R)-(3-(5-(1-(quinuclidin-3-yl)-1H-1,2,3-triazol-4-yl)thiophen-2-yl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1403993-19-0
(R)-3-(4-(5-bromothiophen-2-yl)-1H-1,2,3-triazol-1-yl) quinuclidine

: 87199-15-3
[3-(hydroxymethyl)phenyl]boronic acid

: 1404051-40-6
(R)-(3-(5-(1-(quinuclidin-3-yl)-1H-1,2,3-triazol-4-yl)thiophen-2-yl)phenyl)methanol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 150 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation; Sealed tube;
DOI:10.1016/j.ejmech.2019.06.049

Reference yield: 75.0%

: 1404051-40-6
(R)-(3-(5-(1-(quinuclidin-3-yl)-1H-1,2,3-triazol-4-yl)thiophen-2-yl)phenyl)methanol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 150 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 105995-73-1
2-bromo-5-ethynyl thiophene

: 1404051-40-6
(R)-(3-(5-(1-(quinuclidin-3-yl)-1H-1,2,3-triazol-4-yl)thiophen-2-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate / methanol / 6 h / 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation; Sealed tube

With imidazole-1-sulfonyl azide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(ll) sulfate pentahydrate; potassium carbonate; In methanol; ethanol; toluene; 1.1: |Huisgen Cycloaddition / 1.2: |Huisgen Cycloaddition / 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.ejmech.2019.06.049