Technology Process of (S,S,S)-hydrochloride*NH2-γ-(Et)ACHA-OBn
There total 8 articles about (S,S,S)-hydrochloride*NH2-γ-(Et)ACHA-OBn which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane; water;
DOI:10.1021/ja103233a
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 3-nitrobenzoic acid; (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine / dichloromethane / 0.02 h / 20 °C
1.2: 36 h / 23 °C
2.1: sodium tetrahydroborate; methanol / 0 °C
3.1: Jones reagent / acetone / 5 h / 0 - 20 °C
4.1: hydrogen / Raney nickel / methanol / 24 h / 2068.65 Torr / Inert atmosphere
5.1: chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C
5.2: 12 h / 0 - 20 °C
6.1: caesium carbonate / N,N-dimethyl-formamide
7.1: hydrogenchloride / 1,4-dioxane
With
hydrogenchloride; methanol; sodium tetrahydroborate; Jones reagent; chloro-trimethyl-silane; hydrogen; caesium carbonate;
(R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine; 3-nitrobenzoic acid;
In
1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
1.1: Michael Condensation / 1.2: Michael Condensation;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / Raney nickel / methanol / 24 h / 2068.65 Torr / Inert atmosphere
2.1: chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C
2.2: 12 h / 0 - 20 °C
3.1: caesium carbonate / N,N-dimethyl-formamide
4.1: hydrogenchloride / 1,4-dioxane
With
hydrogenchloride; chloro-trimethyl-silane; hydrogen; caesium carbonate;
Raney nickel;
In
1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
