N-(4-methylbenzenesulphonyl)-4-methylbenzene-trifluoromethyl sulfoximine

Base Information

• Chemical Name: N-(4-methylbenzenesulphonyl)-4-methylbenzene-trifluoromethyl sulfoximine
• CAS No.: 1264737-65-6
• Molecular Formula: C₁₅H₁₄F₃NO₃S₂
• Molecular Weight: 377.408
• Mol file: 1264737-65-6.mol

Synonyms:N-(4-methylbenzenesulphonyl)-4-methylbenzene-trifluoromethyl sulfoximine

Chemical Property of N-(4-methylbenzenesulphonyl)-4-methylbenzene-trifluoromethyl sulfoximine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-methylbenzenesulphonyl)-4-methylbenzene-trifluoromethyl sulfoximine

There total 4 articles about N-(4-methylbenzenesulphonyl)-4-methylbenzene-trifluoromethyl sulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-(4-methylbenzenesulfonyl) 4-methylphenyl sulfonimidoyl fluoride (1264737-51-0) + (trifluoromethyl)trimethylsilane (81290-20-2) → N-(4-methylbenzenesulphonyl)-4-methylbenzene-trifluoromethyl sulfoximine (1264737-65-6)

Guidance literature:

N-(4-methylbenzenesulfonyl) 4-methylphenyl sulfonimidoyl fluoride; (trifluoromethyl)trimethylsilane; In tetrahydrofuran; at 21 ℃; for 0.166667h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 21 ℃; for 12.5h; Inert atmosphere;

DOI:10.1021/ol103030w

Reference yield:

4-methylbenzenesulfinyl chloride (10439-23-3) → N-(4-methylbenzenesulphonyl)-4-methylbenzene-trifluoromethyl sulfoximine (1264737-65-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene / 21 - 85 °C

2.1: potassium fluoride; 18-crown-6 ether / acetonitrile / 16 h / 21 °C / Inert atmosphere

3.1: tetrahydrofuran / 0.17 h / 21 °C / Inert atmosphere

3.2: 12.5 h / 21 °C / Inert atmosphere

With potassium fluoride; 18-crown-6 ether; In tetrahydrofuran; toluene; acetonitrile;

DOI:10.1021/ol103030w

Reference yield:

N-(4-methylbenzenesulfonyl) 4-methylphenyl sulfonimidoyl chloride (108875-13-4) → N-(4-methylbenzenesulphonyl)-4-methylbenzene-trifluoromethyl sulfoximine (1264737-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium fluoride; 18-crown-6 ether / acetonitrile / 16 h / 21 °C / Inert atmosphere

2.1: tetrahydrofuran / 0.17 h / 21 °C / Inert atmosphere

2.2: 12.5 h / 21 °C / Inert atmosphere

With potassium fluoride; 18-crown-6 ether; In tetrahydrofuran; acetonitrile;

DOI:10.1021/ol103030w

upstream raw materials:

4-methylbenzenesulfinyl chloride

N-(4-methylbenzenesulfonyl) 4-methylphenyl sulfonimidoyl fluoride

(trifluoromethyl)trimethylsilane

N-(4-methylbenzenesulfonyl) 4-methylphenyl sulfonimidoyl chloride