2-Thioxo-imidazolidine-1,3-dicarboxylic acid dibenzyl ester

Base Information

• Chemical Name: 2-Thioxo-imidazolidine-1,3-dicarboxylic acid dibenzyl ester
• CAS No.: 173300-82-8
• Molecular Formula: C₁₉H₁₈N₂O₄S
• Molecular Weight: 370.429
• Mol file: 173300-82-8.mol

Synonyms:2-Thioxo-imidazolidine-1,3-dicarboxylic acid dibenzyl ester

Chemical Property of 2-Thioxo-imidazolidine-1,3-dicarboxylic acid dibenzyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-Thioxo-imidazolidine-1,3-dicarboxylic acid dibenzyl ester

There total 1 articles about 2-Thioxo-imidazolidine-1,3-dicarboxylic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N,N'-ethylenethiourea (96-45-7) + benzyl chloroformate (501-53-1,94274-21-2) → 2-Thioxo-imidazolidine-1,3-dicarboxylic acid dibenzyl ester (173300-82-8)

Guidance literature:

N,N'-ethylenethiourea; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

benzyl chloroformate; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.inorgchem.5b00369

Reference yield:

2-Thioxo-imidazolidine-1,3-dicarboxylic acid dibenzyl ester (173300-82-8) → 1-benzyloxycarbonylpyrrolidine (25070-74-0) + 2-Thioxo-imidazolidine-1-carboxylic acid benzyl ester

Guidance literature:

With pyrrolidine; In 1,4-dioxane; for 7h; Yield given. Yields of byproduct given; Heating;

DOI:10.1039/P19950002953

Reference yield:

pyrrolidine (123-75-1) + 2-Thioxo-imidazolidine-1,3-dicarboxylic acid dibenzyl ester (173300-82-8) → 1-benzyloxycarbonylpyrrolidine (25070-74-0) + 2-Thioxo-imidazolidine-1-carboxylic acid benzyl ester

Guidance literature:

In 1,4-dioxane; for 7h; Yield given. Yields of byproduct given; Heating;

DOI:10.1039/P19950002953

upstream raw materials:

N,N'-ethylenethiourea

benzyl chloroformate

Downstream raw materials:

1-benzyloxycarbonylpyrrolidine