(S)-1-(2,2-diphenylacetyl)-4-(3-[4-fluorophenyl]prop-2-yn-1-yl)piperazine-2-carboxylic acid

Base Information

Chemical Name:(S)-1-(2,2-diphenylacetyl)-4-(3-[4-fluorophenyl]prop-2-yn-1-yl)piperazine-2-carboxylic acid
CAS No.:1448678-97-4
Molecular Formula:C₂₈H₂₅FN₂O₃
Molecular Weight:456.517
Hs Code.:

Synonyms:(S)-1-(2,2-diphenylacetyl)-4-(3-[4-fluorophenyl]prop-2-yn-1-yl)piperazine-2-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(2,2-diphenylacetyl)-4-(3-[4-fluorophenyl]prop-2-yn-1-yl)piperazine-2-carboxylic acid

Chemical Property:

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Technology Process of (S)-1-(2,2-diphenylacetyl)-4-(3-[4-fluorophenyl]prop-2-yn-1-yl)piperazine-2-carboxylic acid

There total 4 articles about (S)-1-(2,2-diphenylacetyl)-4-(3-[4-fluorophenyl]prop-2-yn-1-yl)piperazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1448679-57-9
C₂₉H₂₇FN₂O₃

: 1448678-97-4
(S)-1-(2,2-diphenylacetyl)-4-(3-[4-fluorophenyl]prop-2-yn-1-yl)piperazine-2-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

: 796096-64-5
(S)-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 1448678-97-4
(S)-1-(2,2-diphenylacetyl)-4-(3-[4-fluorophenyl]prop-2-yn-1-yl)piperazine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 30 °C

2.1: hydrogenchloride; methanol / 20 °C

2.2: 0.17 h / 0 - 20 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

With hydrogenchloride; methanol; lithium hydroxide monohydrate; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 40274-29-1
1-(3-bromoprop-1-yn-1-yl)-4-fluorobenzene

: 1448678-97-4
(S)-1-(2,2-diphenylacetyl)-4-(3-[4-fluorophenyl]prop-2-yn-1-yl)piperazine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 30 °C

2.1: hydrogenchloride; methanol / 20 °C

2.2: 0.17 h / 0 - 20 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

With hydrogenchloride; methanol; lithium hydroxide monohydrate; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;