796096-64-5 Usage
Uses
Used in Pharmaceutical Research and Drug Development:
(S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with enhanced efficacy and selectivity. Its unique stereochemistry allows for the creation of enantiomerically pure compounds, which is crucial in ensuring the desired biological activity and minimizing potential side effects.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester is utilized as a versatile building block for the design and synthesis of novel bioactive molecules. Its potential biological activities and pharmacological properties make it an important compound for exploring new therapeutic agents and advancing drug discovery efforts.
Used in Stereoselective Synthesis:
The (S)-stereoisomer configuration of (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester is particularly useful in stereoselective synthesis, where the spatial arrangement of atoms is critical for the compound's biological activity. It is employed to produce enantiomerically pure compounds, which are essential in pharmaceuticals to avoid the adverse effects that may arise from the less active or unwanted enantiomer.
Used in the Synthesis of Bioactive Compounds:
(S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester is used as a precursor in the synthesis of various bioactive compounds, leveraging its reactivity and functional groups to create molecules with potential therapeutic applications. This includes the development of compounds targeting specific receptors or enzymes, contributing to the treatment of various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 796096-64-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,9,6,0,9 and 6 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 796096-64:
(8*7)+(7*9)+(6*6)+(5*0)+(4*9)+(3*6)+(2*6)+(1*4)=225
225 % 10 = 5
So 796096-64-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H20N2O4/c1-11(2,3)17-10(15)13-6-5-12-7-8(13)9(14)16-4/h8,12H,5-7H2,1-4H3/t8-/m0/s1
796096-64-5Relevant academic research and scientific papers
Synthesis of Enantiopure Piperazines via Asymmetric Lithiation-Trapping of N-Boc Piperazines: Unexpected Role of the Electrophile and Distal N-Substituent
Firth, James D.,O'Brien, Peter,Ferris, Leigh
, p. 651 - 659 (2016/01/29)
A new method for the synthesis of enantiopure α-substituted piperazines via direct functionalization of the intact piperazine ring is described. The approach utilizes the asymmetric lithiation-substitution of an α-methylbenzyl-functionalized N-Boc piperaz
Advances in the kinetic and dynamic kinetic resolution of piperazine-2-carboxylic acid derivatives with Candida Antarctica lipase A; Structural requirements for enantioselective N-acylation
Hietanen, Ari,Lundell, Katri,Kanerva, Liisa T.,Liljeblad, Arto
experimental part, p. 60 - 74 (2012/03/26)
The kinetic resolution of piperazine-2-carboxylic acid was studied as its N-4- and N-1-Bocpiperazine-2-carboxylic acid methyl esters, rac-1 and -2, respectively. Lipase A from Candida antarctica (CAL-A) catalyzed highly enantioselective (e>200 for rac-1 and 200 for rac-2) Nacylation of both compounds with 2,2,2-trifluoroethyl butanoate in TBME. Aldehyde-based dynamic kinetic resolution of rac-1 with vinyl butanoate in acetonitrile gave up to 75% product yield with S-absolute configuration in 48 hours. The present results together with literature data suggest that CAL-A -catalyzed N-acylation is enhanced in terms of reaction rate or enantioselectivity when an electron rich structure, such as carboxylic ester or aromatic ring, is attached to the asymmetric center next to the secondary ring nitrogen. ARKAT-USA, Inc.
