Benzenamine, 3-bromo-2,4,6-trifluoro-

Base Information

Chemical Name:Benzenamine, 3-bromo-2,4,6-trifluoro-
CAS No.:762297-95-0
Molecular Formula:C₆H₃BrF₃N
Molecular Weight:225.996
Hs Code.:
DSSTox Substance ID:DTXSID201297587

Synonyms:Benzenamine, 3-bromo-2,4,6-trifluoro-;3-Bromo-2,4,6-trifluoroaniline;762297-95-0;SCHEMBL1962497;MTFDNVGNGPISNO-UHFFFAOYSA-N;DTXSID201297587;3-Bromo-2,4,6-trifluorobenzenamine;AT13720;3-AMINO-1-BROMO-2,4,6-TRIFLUOROBENZENE

Suppliers and Price of Benzenamine, 3-bromo-2,4,6-trifluoro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Benzenamine, 3-bromo-2,4,6-trifluoro-

Chemical Property:

Vapor Pressure:0.442mmHg at 25°C
Boiling Point:194.4±35.0 °C(Predicted)
PKA:0.80±0.10(Predicted)
Density:1.875±0.06 g/cm3(Predicted)
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:224.94010
Heavy Atom Count:11
Complexity:146

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=C(C(=C1F)Br)F)N)F

Technology Process of Benzenamine, 3-bromo-2,4,6-trifluoro-

There total 2 articles about Benzenamine, 3-bromo-2,4,6-trifluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 762297-93-8
2-bromo-1,3,5-trifluoro-4-nitro-benzene

: 762297-95-0
3-bromo-2,4,6-trifluoroaniline

Guidance literature:: With hydrogen; palladium dihydroxide; In ethanol; cyclohexene; at 80 - 85 ℃; for 2.08333h;

Reference yield:

: 2367-76-2
2,4,6-trifluorobromobenzene

: 762297-95-0
3-bromo-2,4,6-trifluoroaniline

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / HNO₃; H₂SO₄ / 2 h / 0 °C

2: aq. NH₄Cl; Fe / ethanol; tetrahydrofuran / 2 h / Heating

With sulfuric acid; nitric acid; iron; ammonium chloride; In tetrahydrofuran; ethanol;
DOI:10.1021/jm060381c

Reference yield: 38.0%

: 762297-95-0
3-bromo-2,4,6-trifluoroaniline

: 1314734-58-1
5-bromo-N-methoxy-N-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide

: (3-amino-2,4,6-trifluorophenyl)(5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)methanone

Guidance literature:: 3-bromo-2,4,6-trifluoroaniline; With isopropylmagnesium chloride; In tetrahydrofuran; at -10 - 25 ℃; for 0.333333h;

With chloro-trimethyl-silane; In tetrahydrofuran; at -10 - 25 ℃; for 1.66667h;

5-bromo-N-methoxy-N-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide; With isopropylmagnesium chloride; In tetrahydrofuran; at -10 - 25 ℃; for 2.16667h;