tert-butyl 4-[2,4,6-trifluoro-3-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridine carboxylate

Base Information

Chemical Name:tert-butyl 4-[2,4,6-trifluoro-3-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridine carboxylate
CAS No.:762298-03-3
Molecular Formula:C₂₀H₂₅F₃N₂O₃
Molecular Weight:398.425
Hs Code.:

Synonyms:tert-butyl 4-[2,4,6-trifluoro-3-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridine carboxylate

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Chemical Property of tert-butyl 4-[2,4,6-trifluoro-3-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridine carboxylate

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Technology Process of tert-butyl 4-[2,4,6-trifluoro-3-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridine carboxylate

There total 3 articles about tert-butyl 4-[2,4,6-trifluoro-3-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridine carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 762297-95-0
3-bromo-2,4,6-trifluoroaniline

: 762298-03-3
tert-butyl 4-[2,4,6-trifluoro-3-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridine carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 2 h / 20 °C

2: K₂CO₃ / PdCl₂dppf / dimethylformamide / 80 °C

With potassium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1021/jm060381c

Reference yield:

: 762297-93-8
2-bromo-1,3,5-trifluoro-4-nitro-benzene

: 762298-03-3
tert-butyl 4-[2,4,6-trifluoro-3-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridine carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NH₄Cl; Fe / ethanol; tetrahydrofuran / 2 h / Heating

2: Et₃N / tetrahydrofuran / 2 h / 20 °C

3: K₂CO₃ / PdCl₂dppf / dimethylformamide / 80 °C

With iron; potassium carbonate; ammonium chloride; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 3: Suzuki coupling;
DOI:10.1021/jm060381c

Reference yield:

: 2367-76-2
2,4,6-trifluorobromobenzene

: 762298-03-3
tert-butyl 4-[2,4,6-trifluoro-3-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridine carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / HNO₃; H₂SO₄ / 2 h / 0 °C

2: aq. NH₄Cl; Fe / ethanol; tetrahydrofuran / 2 h / Heating

3: Et₃N / tetrahydrofuran / 2 h / 20 °C

4: K₂CO₃ / PdCl₂dppf / dimethylformamide / 80 °C

With sulfuric acid; nitric acid; iron; potassium carbonate; ammonium chloride; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 4: Suzuki coupling;
DOI:10.1021/jm060381c