(3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanamide

Base Information

Chemical Name:(3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanamide
CAS No.:479480-56-3
Molecular Formula:C₁₃H₂₄F₂N₂O₂S
Molecular Weight:310.409
Hs Code.:

Synonyms:(3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanamide

Chemical Property:

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Technology Process of (3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanamide

There total 3 articles about (3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 479480-54-1
ethyl (3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanoate

: 479480-56-3
(3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanamide

Guidance literature:: With ammonia; In diethyl ether; at 20 ℃; for 18h;
DOI:10.1021/jo0259313

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 479480-56-3
(3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: CuSO₄; molecular sieves / CH₂Cl₂

2.1: Zn / tetrahydrofuran

2.2: tetrahydrofuran / 18 h / 20 °C

3.1: 75 percent / NH₃ / diethyl ether / 18 h / 20 °C

With molecular sieve; ammonia; copper(II) sulfate; zinc; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo0259313

Reference yield:

: 336105-28-3
(R_S,E)-N-(cyclohexylmethylene)-2-methylpropane-2-sulfinamide

: 479480-56-3
(3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Zn / tetrahydrofuran

1.2: tetrahydrofuran / 18 h / 20 °C

2.1: 75 percent / NH₃ / diethyl ether / 18 h / 20 °C

With ammonia; zinc; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo0259313