tert-butyl 4-((2-chlorophenyl)methyl)aminopiperidine carboxylate

Base Information

• Chemical Name: tert-butyl 4-((2-chlorophenyl)methyl)aminopiperidine carboxylate
• CAS No.: 359877-83-1
• Molecular Formula: C₁₇H₂₅ClN₂O₂
• Molecular Weight: 324.851
• Mol file: 359877-83-1.mol

Synonyms:tert-butyl 4-((2-chlorophenyl)methyl)aminopiperidine carboxylate

Chemical Property of tert-butyl 4-((2-chlorophenyl)methyl)aminopiperidine carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-((2-chlorophenyl)methyl)aminopiperidine carboxylate

There total 1 articles about tert-butyl 4-((2-chlorophenyl)methyl)aminopiperidine carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 2-CHLOROBENZYLAMINE (89-97-4) → tert-butyl 4-((2-chlorophenyl)methyl)aminopiperidine carboxylate (359877-83-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane;

DOI:10.1016/S0960-894X(01)00727-2

Reference yield:

tert-butyl 4-((2-chlorophenyl)methyl)aminopiperidine carboxylate (359877-83-1) + 4-methoxyphenyl-acetic chloride (4693-91-8) → N-((2-chlorophenyl)methyl)-N-(1-(tert-butyloxycarbonyl)piperidin-4-yl)-4-methoxyphenylacetamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; water;

Reference yield:

chloroacetyl chloride (79-04-9) + tert-butyl 4-((2-chlorophenyl)methyl)aminopiperidine carboxylate (359877-83-1) → 4-[chloroacetyl-(2-chloro-benzyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:

With potassium carbonate; In dichloromethane; at 0 ℃;

DOI:10.1016/S0960-894X(01)00727-2

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

2-CHLOROBENZYLAMINE