Technology Process of sodium (3-{[4'-(2-hydroxyethoxy)-2,2',6'-trimethylbiphenyl-3-yl]methoxy}-9H-fluoren-9-yl)acetate
There total 12 articles about sodium (3-{[4'-(2-hydroxyethoxy)-2,2',6'-trimethylbiphenyl-3-yl]methoxy}-9H-fluoren-9-yl)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 2 h / 70 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride; Glauber's salt / tetrahydrofuran / 1.33 h / 20 °C / Under cooling with ice; Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 - 50 °C
4.1: zinc / tetrahydrofuran / 80 °C / Inert atmosphere
4.2: 20 - 50 °C
5.1: hydrogenchloride; caesium carbonate / ethanol; water; tetrahydrofuran / 20 - 50 °C
5.2: 4 h / 50 °C
6.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 4 h / 20 °C / 1474.5 Torr
7.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 50 °C
7.2: 20 °C
With
hydrogenchloride; potassium phosphate; lithium aluminium tetrahydride; Glauber's salt; water; hydrogen; sodium hydride; caesium carbonate; sodium hydroxide;
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium 10% on activated carbon; palladium diacetate; zinc;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
ethyl (3-{[4'-(2-acetoxyethoxy)-2,2',6'-trimethylbiphenyl-3-yl]methoxy}-9H-fluoren-9-yl)acetate;
With
water; sodium hydroxide;
In
tetrahydrofuran; ethanol;
at 50 ℃;
for 18h;
With
hydrogenchloride;
In
tetrahydrofuran; ethanol; water;
at 20 ℃;
With
sodium hydroxide;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sulfuric acid / 22 h / Reflux
1.2: pH 7 - 8
2.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 2 h / 70 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride; Glauber's salt / tetrahydrofuran / 1.33 h / 20 °C / Under cooling with ice; Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 - 50 °C
5.1: zinc / tetrahydrofuran / 80 °C / Inert atmosphere
5.2: 20 - 50 °C
6.1: hydrogenchloride; caesium carbonate / ethanol; water; tetrahydrofuran / 20 - 50 °C
6.2: 4 h / 50 °C
7.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 4 h / 20 °C / 1474.5 Torr
8.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 50 °C
8.2: 20 °C
With
hydrogenchloride; potassium phosphate; lithium aluminium tetrahydride; Glauber's salt; sulfuric acid; water; hydrogen; sodium hydride; caesium carbonate; sodium hydroxide;
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium 10% on activated carbon; palladium diacetate; zinc;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil;
