2-(4-chlorophenyl)-4,6-diphenylnicotinonitrile

Base Information

• Chemical Name: 2-(4-chlorophenyl)-4,6-diphenylnicotinonitrile
• CAS No.: 55249-92-8
• Molecular Formula: C₂₄H₁₅ClN₂
• Molecular Weight: 366.849
• Mol file: 55249-92-8.mol

Synonyms:2-(4-chlorophenyl)-4,6-diphenylnicotinonitrile

Chemical Property of 2-(4-chlorophenyl)-4,6-diphenylnicotinonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-chlorophenyl)-4,6-diphenylnicotinonitrile

There total 2 articles about 2-(4-chlorophenyl)-4,6-diphenylnicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-Chlorophenylboronic acid (1679-18-1) + 2-(3-oxo-1,3-diphenylpropyl)malononitrile (62940-90-3,77609-06-4) → 2-(4-chlorophenyl)-4,6-diphenylnicotinonitrile (55249-92-8)

Guidance literature:

With [2,2]bipyridinyl; palladium diacetate; toluene-4-sulfonic acid; In 1,2-dichloro-ethane; at 20 ℃; for 24h; Irradiation;

DOI:10.1021/acs.joc.0c01703

Reference yield:

benzalacetophenone (94-41-7) → 2-(4-chlorophenyl)-4,6-diphenylnicotinonitrile (55249-92-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / 1,2-dichloro-ethane / 12 h / 20 °C

2: palladium diacetate; [2,2]bipyridinyl; toluene-4-sulfonic acid / 1,2-dichloro-ethane / 24 h / 20 °C / Irradiation

With [2,2]bipyridinyl; palladium diacetate; potassium carbonate; toluene-4-sulfonic acid; In 1,2-dichloro-ethane;

DOI:10.1021/acs.joc.0c01703

upstream raw materials:

4-Chlorophenylboronic acid

2-(3-oxo-1,3-diphenylpropyl)malononitrile

benzalacetophenone