(R)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone O-methyloxime

Base Information

Chemical Name:(R)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone O-methyloxime
CAS No.:1372526-77-6
Molecular Formula:C₂₈H₃₉ClN₂O₃
Molecular Weight:487.082
Hs Code.:

Synonyms:(R)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone O-methyloxime

Suppliers and Price of (R)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone O-methyloxime

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Chemical Property of (R)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone O-methyloxime

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Technology Process of (R)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone O-methyloxime

There total 5 articles about (R)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone O-methyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1372526-76-5
(4-chlorophenyl)(3-(piperidin-4-ylmethoxy)phenyl)methanone O-methyloxime

: 77495-66-0
(R)-1,2-epoxyoctane

: 1372526-77-6
(R)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone O-methyloxime

Guidance literature:: (4-chlorophenyl)(3-(piperidin-4-ylmethoxy)phenyl)methanone O-methyloxime; With trimethylaluminum; In dichloromethane; at 0 ℃; for 0.25h;

(R)-1,2-epoxyoctane; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1021/jm201608g

Reference yield:

: 1372526-73-2
(4-chlorophenyl)(3-hydroxyphenyl)methanone O-methyloxime

: 1372526-77-6
(R)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone O-methyloxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: trimethylaluminum / dichloromethane / 0.25 h / 0 °C

3.2: 4 h / 0 °C

With di-isopropyl azodicarboxylate; trimethylaluminum; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1.1: Mitsunobu reaction;
DOI:10.1021/jm201608g

Reference yield:

: 62810-39-3
(4-chlorophenyl)(3-hydroxyphenyl)methanone

: 1372526-77-6
(R)-(4-chlorophenyl)(3-((1-(2-hydroxyoctyl)piperidin-4-yl)methoxy)phenyl)methanone O-methyloxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 16 h / 105 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: trimethylaluminum / dichloromethane / 0.25 h / 0 °C

4.2: 4 h / 0 °C

With pyridine; di-isopropyl azodicarboxylate; trimethylaluminum; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 2.1: Mitsunobu reaction;
DOI:10.1021/jm201608g