(E)-4-[(R)-4-((R)-3-Benzyloxy-1-iodo-propyl)-2-oxo-oxazolidin-3-yl]-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-but-2-enoic acid methyl ester

Base Information

Chemical Name:(E)-4-[(R)-4-((R)-3-Benzyloxy-1-iodo-propyl)-2-oxo-oxazolidin-3-yl]-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-but-2-enoic acid methyl ester
CAS No.:117398-87-5
Molecular Formula:C₂₄H₃₂INO₇
Molecular Weight:573.425
Hs Code.:

Synonyms:(E)-4-[(R)-4-((R)-3-Benzyloxy-1-iodo-propyl)-2-oxo-oxazolidin-3-yl]-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-but-2-enoic acid methyl ester

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Chemical Property of (E)-4-[(R)-4-((R)-3-Benzyloxy-1-iodo-propyl)-2-oxo-oxazolidin-3-yl]-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-but-2-enoic acid methyl ester

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Technology Process of (E)-4-[(R)-4-((R)-3-Benzyloxy-1-iodo-propyl)-2-oxo-oxazolidin-3-yl]-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-but-2-enoic acid methyl ester

There total 8 articles about (E)-4-[(R)-4-((R)-3-Benzyloxy-1-iodo-propyl)-2-oxo-oxazolidin-3-yl]-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-but-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 117398-86-4
(E)-4-[(R)-4-((S)-3-Benzyloxy-1-hydroxy-propyl)-2-oxo-oxazolidin-3-yl]-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-but-2-enoic acid methyl ester

: 117398-87-5
(E)-4-[(R)-4-((R)-3-Benzyloxy-1-iodo-propyl)-2-oxo-oxazolidin-3-yl]-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-but-2-enoic acid methyl ester

Guidance literature:: With pyridine; trifluoromethylsulfonic anhydride; sodium iodide;
DOI:10.1039/c39880000261

Reference yield:

: (E)-4-{(R)-4-[(S)-3-Benzyloxy-1-(2-ethoxy-ethoxy)-propyl]-2-oxo-oxazolidin-3-yl}-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-but-2-enoic acid methyl ester

: 117398-87-5
(E)-4-[(R)-4-((R)-3-Benzyloxy-1-iodo-propyl)-2-oxo-oxazolidin-3-yl]-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-but-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: p-toluenesulphonic acid / ethane-1,2-diol; various solvent(s)

2: 65 percent / (CF₃SO₂)2O, pyridine, NaI

With pyridine; trifluoromethylsulfonic anhydride; toluene-4-sulfonic acid; sodium iodide; In ethylene glycol;
DOI:10.1039/c39880000261

Reference yield:

: 24400-75-7
ethylene-cetal de la bromo-5 pentanone-2

: 117398-87-5
(E)-4-[(R)-4-((R)-3-Benzyloxy-1-iodo-propyl)-2-oxo-oxazolidin-3-yl]-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-but-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

2: 50 percent / lithium di-isopropylamide

4: 65 percent / (CF₃SO₂)2O, pyridine, NaI

With pyridine; trifluoromethylsulfonic anhydride; sodium iodide; lithium diisopropyl amide;
DOI:10.1039/c39880000261