Lithium [4-(4-{2-[(diaminomethylene)amino]ethoxy}-3,5-diiodophenoxy)-3,5-diiodophenyl]acetate

Base Information

• Chemical Name: Lithium [4-(4-{2-[(diaminomethylene)amino]ethoxy}-3,5-diiodophenoxy)-3,5-diiodophenyl]acetate
• CAS No.: 1300559-73-2
• Molecular Formula: C₁₇H₁₄I₄N₃O₄*Li
• Molecular Weight: 838.875
• Mol file: 1300559-73-2.mol

Synonyms:Lithium [4-(4-{2-[(diaminomethylene)amino]ethoxy}-3,5-diiodophenoxy)-3,5-diiodophenyl]acetate

Chemical Property of Lithium [4-(4-{2-[(diaminomethylene)amino]ethoxy}-3,5-diiodophenoxy)-3,5-diiodophenyl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Lithium [4-(4-{2-[(diaminomethylene)amino]ethoxy}-3,5-diiodophenoxy)-3,5-diiodophenyl]acetate

There total 20 articles about Lithium [4-(4-{2-[(diaminomethylene)amino]ethoxy}-3,5-diiodophenoxy)-3,5-diiodophenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H17I4N3O4 → Lithium [4-(4-{2-[(diaminomethylene)amino]ethoxy}-3,5-diiodophenoxy)-3,5-diiodophenyl]acetate (1300559-73-2)

Guidance literature:

With lithium hydroxide;

Reference yield:

4-methoxy-phenol (150-76-5) → Lithium [4-(4-{2-[(diaminomethylene)amino]ethoxy}-3,5-diiodophenoxy)-3,5-diiodophenyl]acetate (1300559-73-2)

Guidance literature:

Multi-step reaction with 9 steps

1.1: pyridine; p-toluenesulfonyl chloride / 0.5 h / 95 - 100 °C

1.2: 2 h / 125 °C / Inert atmosphere

2.1: hydrogen / 5% Pd-CaCO3 / ethanol

3.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C

3.2: 1 h / 20 °C

4.1: phosphorus; hydrogen iodide; acetic acid / 1 h / Reflux

5.1: iodine; ammonia / methanol

6.1: thionyl chloride / 48 h / Reflux

7.1: caesium carbonate / acetone / 72 h / 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 24 h / 20 °C

9.1: lithium hydroxide

With pyridine; phosphorus; thionyl chloride; sulfuric acid; ammonia; hydrogen iodide; hydrogen; iodine; sodium hydride; caesium carbonate; acetic acid; p-toluenesulfonyl chloride; lithium hydroxide; sodium nitrite; 5% Pd-CaCO3; In methanol; ethanol; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

(4-hydroxy-3,5-dinitro-phenyl)-acetic acid ethyl ester (83799-60-4) → Lithium [4-(4-{2-[(diaminomethylene)amino]ethoxy}-3,5-diiodophenoxy)-3,5-diiodophenyl]acetate (1300559-73-2)

Guidance literature:

Multi-step reaction with 9 steps

1.1: pyridine; p-toluenesulfonyl chloride / 0.5 h / 95 - 100 °C

1.2: 2 h / 125 °C / Inert atmosphere

2.1: hydrogen / 5% Pd-CaCO3 / ethanol

3.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C

3.2: 1 h / 20 °C

4.1: phosphorus; hydrogen iodide; acetic acid / 1 h / Reflux

5.1: iodine; ammonia / methanol

6.1: thionyl chloride / 48 h / Reflux

7.1: caesium carbonate / acetone / 72 h / 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 24 h / 20 °C

9.1: lithium hydroxide

With pyridine; phosphorus; thionyl chloride; sulfuric acid; ammonia; hydrogen iodide; hydrogen; iodine; sodium hydride; caesium carbonate; acetic acid; p-toluenesulfonyl chloride; lithium hydroxide; sodium nitrite; 5% Pd-CaCO3; In methanol; ethanol; N,N-dimethyl-formamide; acetone; mineral oil;

upstream raw materials:

tetrac

4-methoxy-phenol

2-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)acetic acid

methyl {4-[4-(2-chloroethoxy)-3,5-diiodophenoxy]-3,5-diiodophenyl}-acetate