3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID

Base Information

Chemical Name:3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID
CAS No.:67-30-1
Molecular Formula:C14H8 I4 O4
Molecular Weight:747.833
Hs Code.:2918990090
European Community (EC) Number:200-649-1
UNII:PA7UX1FFYQ
DSSTox Substance ID:DTXSID5048186
Nikkaji Number:J192.547D
Wikidata:Q27092911
Pharos Ligand ID:WMQ584B1TPMP
Metabolomics Workbench ID:146385
ChEMBL ID:CHEMBL549748
Mol file:67-30-1.mol

Synonyms:Aceticacid, [4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]- (8CI); Thyroaceticacid, 3,3',5,5'-tetraiodo- (6CI); 3,3',5,5'-Tetraiodothyroacetic acid;3,5,3',5'-Tetraiodothyroacetic acid; Tetrac; Tetraiodothyroacetic acid

Suppliers and Price of 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,5,3'',5''-TetraiodoThyroaceticAcid
50mg
$ 100.00

TCI Chemical
3,3',5,5'-Tetraiodothyroacetic Acid
500MG
$ 592.00

TCI Chemical
3,3',5,5'-Tetraiodothyroacetic Acid
100MG
$ 194.00

Sigma-Aldrich
3,3′,5,5′-Tetraiodothyroacetic acid
100mg
$ 342.00

Sigma-Aldrich
3,3′,5,5′-Tetraiodothyroacetic acid
25mg
$ 115.00

Medical Isotopes, Inc.
3,5,3??,5??-TetraiodoThyroaceticAcid
25 mg
$ 650.00

Crysdot
2-(4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)aceticacid 97%
250mg
$ 595.00

ChemScene
Tetrac
25mg
$ 100.00

ChemScene
Tetrac
10mg
$ 50.00

Chem-Impex
3,3',5,5'-Tetraiodothyroaceticacid,≥98%(HPLC)Hazmat ≥98%(HPLC)
500MG
$ 948.15

Total 35 raw suppliers

Chemical Property of 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID

Chemical Property:

Melting Point:219-220 °C (decomp)
Boiling Point:544.8±50.0 °C(Predicted)
PKA:3.98±0.10(Predicted)
Flash Point:283.3oC
PSA：66.76000
Density:2.727±0.06 g/cm3(Predicted)
LogP:5.23000
Storage Temp.:−20°C
Solubility.:acetone: soluble19.60 - 20.40mg/mL, clear, colorless (or faintly
XLogP3:5.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:747.6601
Heavy Atom Count:22
Complexity:373

Purity/Quality:

99%, ^*data from raw suppliers

3,5,3'',5''-TetraiodoThyroaceticAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s): T+
Hazard Codes:T+
Statements: 28
Safety Statements: 45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(=O)O
Uses 3,3′,5,5′-Tetraiodothyroacetic acid has been used: as a positive control to study the effects of ioxynil (IOX) diethylstilbestrol (DES) exposure on zebrafish embryosto study its effects on long-term potentiation (LTP) and long-term depression (LTD) in the dentate gyrus in urethane-anesthetized male ratsto determine its influence on the actions of thyroid-stimulating hormonethyroid-stimulating immunoglobulins in orbital fibroblast

Technology Process of 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID

There total 14 articles about 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1155-40-4
2-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)acetic acid

: 67-30-1
tetrac

Guidance literature:: With ammonia; iodine; In methanol;

Reference yield:

: 67-30-1
tetrac

Guidance literature:: With water; at 38 ℃; unter Luftzutritt;
DOI:10.1007/BF03019871

Reference yield:

: 83799-60-4
(4-hydroxy-3,5-dinitro-phenyl)-acetic acid ethyl ester

: 67-30-1
tetrac

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; p-toluenesulfonyl chloride / 0.5 h / 95 - 100 °C

1.2: 2 h / 125 °C / Inert atmosphere

2.1: hydrogen / 5% Pd-CaCO3 / ethanol

3.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C

3.2: 1 h / 20 °C

4.1: phosphorus; hydrogen iodide; acetic acid / 1 h / Reflux

5.1: iodine; ammonia / methanol

With pyridine; phosphorus; sulfuric acid; ammonia; hydrogen iodide; hydrogen; iodine; acetic acid; p-toluenesulfonyl chloride; sodium nitrite; 5% Pd-CaCO3; In methanol; ethanol;