Technology Process of methyl {4-[4-(2-chloroethoxy)-3,5-diiodophenoxy]-3,5-diiodophenyl}-acetate
There total 9 articles about methyl {4-[4-(2-chloroethoxy)-3,5-diiodophenoxy]-3,5-diiodophenyl}-acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
acetone;
at 20 ℃;
for 72h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: pyridine; p-toluenesulfonyl chloride / 0.5 h / 95 - 100 °C
1.2: 2 h / 125 °C / Inert atmosphere
2.1: hydrogen / 5% Pd-CaCO3 / ethanol
3.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C
3.2: 1 h / 20 °C
4.1: phosphorus; hydrogen iodide; acetic acid / 1 h / Reflux
5.1: iodine; ammonia / methanol
6.1: thionyl chloride / 48 h / Reflux
7.1: caesium carbonate / acetone / 72 h / 20 °C
With
pyridine; phosphorus; thionyl chloride; sulfuric acid; ammonia; hydrogen iodide; hydrogen; iodine; caesium carbonate; acetic acid; p-toluenesulfonyl chloride; sodium nitrite;
5% Pd-CaCO3;
In
methanol; ethanol; acetone;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogen / 5% Pd-CaCO3 / ethanol
2.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C
2.2: 1 h / 20 °C
3.1: phosphorus; hydrogen iodide; acetic acid / 1 h / Reflux
4.1: iodine; ammonia / methanol
5.1: thionyl chloride / 48 h / Reflux
6.1: caesium carbonate / acetone / 72 h / 20 °C
With
phosphorus; thionyl chloride; sulfuric acid; ammonia; hydrogen iodide; hydrogen; iodine; caesium carbonate; acetic acid; sodium nitrite;
5% Pd-CaCO3;
In
methanol; ethanol; acetone;
