(2-(5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

Base Information

Chemical Name:(2-(5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol
CAS No.:1012104-39-0
Molecular Formula:C₃₃H₃₆N₆O₃Si
Molecular Weight:592.773
Hs Code.:

Synonyms:(2-(5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

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Chemical Property of (2-(5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

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Technology Process of (2-(5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

There total 9 articles about (2-(5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1012104-38-9
(2-(5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

: 355004-67-0
(4-methoxypyridin-3-yl)boronic acid

: 1012104-39-0
(2-(5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 100 ℃; for 14h; Inert atmosphere; Sealed vessel;

Reference yield:

: 20274-69-5
(4-fluoro-3-nitrophenyl)methanol

: 1012104-39-0
(2-(5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 150 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr / Inert atmosphere

3: acetonitrile; water; methanol

4: potassium phosphate / copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / tetrahydrofuran / 3 h / 140 °C / Inert atmosphere; Microwave irradiation

5: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 14 h / 100 °C / Inert atmosphere; Sealed vessel

With potassium phosphate; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 62-53-3
aniline

: 1012104-39-0
(2-(5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 150 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr / Inert atmosphere

3: acetonitrile; water; methanol

4: potassium phosphate / copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / tetrahydrofuran / 3 h / 140 °C / Inert atmosphere; Microwave irradiation

5: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 14 h / 100 °C / Inert atmosphere; Sealed vessel

With potassium phosphate; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;