(2-(5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

Base Information

Chemical Name:(2-(5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol
CAS No.:1012104-38-9
Molecular Formula:C₂₇H₃₀BrN₅O₂Si
Molecular Weight:564.557
Hs Code.:

Synonyms:(2-(5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

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Chemical Property of (2-(5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

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Technology Process of (2-(5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

There total 7 articles about (2-(5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 918440-14-9
5-bromo-3-iodo-1-[2-(trimethylsilanyl)ethoxymethyl]-1H-indazole

: 509093-83-8
(2-amino-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

: 1012104-38-9
(2-(5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

Guidance literature:: With potassium phosphate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; In tetrahydrofuran; at 140 ℃; for 3h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 62-53-3
aniline

: 1012104-38-9
(2-(5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 150 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr / Inert atmosphere

3: acetonitrile; water; methanol

4: potassium phosphate / copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / tetrahydrofuran / 3 h / 140 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; hydrogen; N-ethyl-N,N-diisopropylamine; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 53857-57-1
5-bromo-1H-indazole

: 1012104-38-9
(2-(5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0 °C

2.2: 0 - 20 °C

3.1: potassium phosphate / copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / tetrahydrofuran / 3 h / 140 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; iodine; sodium hydride; potassium hydroxide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; In tetrahydrofuran; N,N-dimethyl-formamide;