2-CHLORO-N-(3-CHLOROPHENYL)ACETAMIDE

Base Information

• Chemical Name: 2-CHLORO-N-(3-CHLOROPHENYL)ACETAMIDE
• CAS No.: 2564-05-8
• Molecular Formula: C8H7Cl2NO
• Molecular Weight: 204.056
• Hs Code.: 2924299090
• European Community (EC) Number: 832-087-3
• NSC Number: 8368
• DSSTox Substance ID: DTXSID30180324
• Nikkaji Number: J1.395.871H
• Wikidata: Q83050864
• Mol file: 2564-05-8.mol

Synonyms:Acetanilide,2,3'-dichloro- (6CI,7CI,8CI);2,3'-Dichloroacetanilide;2-Chloro-N-(3-chlorophenyl)acetamide;2-Chloro-N-(m-chlorophenyl)acetamide;N-(3-Chlorophenyl)chloroacetamide;N-(Chloroacetyl)-m-chloroaniline;N-Chloroacetyl-3-chloroaniline;NSC 8368;a-Chloro-N-(3-chlorophenyl)acetamide;

Chemical Property of 2-CHLORO-N-(3-CHLOROPHENYL)ACETAMIDE

Chemical Property:

• Vapor Pressure: 1.62E-05mmHg at 25°C
• Melting Point: 93 °C
• Refractive Index: 1.605
• Boiling Point: 365 °C at 760 mmHg
• PKA: 12.23±0.70(Predicted)
• Flash Point: 174.6 °C
• PSA: 29.10000
• Density: 1.399 g/cm³
• LogP: 2.59030
• Storage Temp.: 2-8°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 202.9904692
• Heavy Atom Count: 12
• Complexity: 163

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-n-(3-chlorophenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)Cl)NC(=O)CCl
• Uses: 2-Chloro-n-(3-chlorophenyl)acetamide is a compound used in the synthesis of novel substituted 2-chloroacetanalides.

Technology Process of 2-CHLORO-N-(3-CHLOROPHENYL)ACETAMIDE

There total 6 articles about 2-CHLORO-N-(3-CHLOROPHENYL)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

chloroacetyl chloride (79-04-9) + 3-chloro-aniline (108-42-9) → 2-chloro-N-(3-chlorophenyl)acetamide (2564-05-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃;

DOI:10.1021/jm1011534

Reference yield: 96.0%

Chloroiodomethane (593-71-5) + m-chlorophenyl isocyanate (2909-38-8) → 2-chloro-N-(3-chlorophenyl)acetamide (2564-05-8)

Guidance literature:

With methyllithium lithium bromide; In diethyl ether; at -78 ℃;

DOI:10.1039/c3cc44255a

Reference yield:

3-chloro-aniline (108-42-9) → 2-chloro-N-(3-chlorophenyl)acetamide (2564-05-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; chloroacetyl chloride; In dichloromethane; at 0 ℃; for 4.33h;

DOI:10.1039/d1md00187f

upstream raw materials:

chloroacetyl chloride

3-chloro-aniline

chloroacetyl isothiocyanate

Chloroiodomethane

Downstream raw materials:

1-[(3-chloro-phenylcarbamoyl)-methyl]-pyridinium; chloride

thiocyanato-acetic acid-(3-chloro-anilide)

2-amino-N-(3-chlorophenyl)acetamide

[3-(3-chloro-phenyl)-4-oxo-thiazolidin-2-ylidene]-cyanamide