2-methyl-2-(methylsulfonyl)-4-(4-phenoxyphenyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Base Information

Chemical Name:2-methyl-2-(methylsulfonyl)-4-(4-phenoxyphenyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide
CAS No.:1289627-05-9
Molecular Formula:C₂₃H₂₉NO₆S
Molecular Weight:447.552
Hs Code.:

Synonyms:2-methyl-2-(methylsulfonyl)-4-(4-phenoxyphenyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-2-(methylsulfonyl)-4-(4-phenoxyphenyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

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Technology Process of 2-methyl-2-(methylsulfonyl)-4-(4-phenoxyphenyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

There total 7 articles about 2-methyl-2-(methylsulfonyl)-4-(4-phenoxyphenyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 1289627-03-7
2-methyl-2-(methylsulfonyl)-4-(4-phenoxyphenyl)butanoic acid

: 1289627-05-9
2-methyl-2-(methylsulfonyl)-4-(4-phenoxyphenyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 - 25 ℃;

Reference yield:

: 4654-39-1
4-bromophenethanol

: 1289627-05-9
2-methyl-2-(methylsulfonyl)-4-(4-phenoxyphenyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Guidance literature:: Multi-step reaction with 7 steps

1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 1 h / 0 - 25 °C

2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 25 °C

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / Reflux

4: sodium periodate; ammonium acetate / water; acetone / 20 - 25 °C

5: pyridine / copper diacetate / dichloromethane / 48 h / 20 - 25 °C

6: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 - 25 °C

7: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 - 25 °C

With pyridine; 1H-imidazole; sodium periodate; lithium hydroxide monohydrate; ammonium acetate; water; iodine; potassium acetate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 85356-68-9
1-bromo-4-(2-iodoethyl)benzene

: 1289627-05-9
2-methyl-2-(methylsulfonyl)-4-(4-phenoxyphenyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 25 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / Reflux

3: sodium periodate; ammonium acetate / water; acetone / 20 - 25 °C

4: pyridine / copper diacetate / dichloromethane / 48 h / 20 - 25 °C

5: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 - 25 °C

6: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 - 25 °C

With pyridine; sodium periodate; lithium hydroxide monohydrate; ammonium acetate; water; potassium acetate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;