N-benzyloxycarbonylamino-3-(4-methoxyphenyl)propionic acid ethyl ester

Base Information

• Chemical Name: N-benzyloxycarbonylamino-3-(4-methoxyphenyl)propionic acid ethyl ester
• CAS No.: 115424-04-9
• Molecular Formula: C₂₀H₂₃NO₅
• Molecular Weight: 357.406
• Mol file: 115424-04-9.mol

Synonyms:N-benzyloxycarbonylamino-3-(4-methoxyphenyl)propionic acid ethyl ester

Chemical Property of N-benzyloxycarbonylamino-3-(4-methoxyphenyl)propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonylamino-3-(4-methoxyphenyl)propionic acid ethyl ester

There total 5 articles about N-benzyloxycarbonylamino-3-(4-methoxyphenyl)propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.64%

benzyl chloroformate (501-53-1,94274-21-2) + O-methyl-L-tyrosine ethyl ester; hydrochloride (6330-11-6) → N-benzyloxycarbonylamino-3-(4-methoxyphenyl)propionic acid ethyl ester (115424-04-9)

Guidance literature:

With potassium carbonate; In water; ethyl acetate; at 0 - 8 ℃; for 0.5h;

DOI:10.1080/00397911.2012.748075

Reference yield:

L-tyrosine ethyl ester (949-67-7) → N-benzyloxycarbonylamino-3-(4-methoxyphenyl)propionic acid ethyl ester (115424-04-9)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / ethyl acetate; H₂O / 0.5 h / 3 - 8 °C

2: K₂CO₃ / dimethylsulfoxide / 16 h / Ambient temperature

With potassium carbonate; In water; dimethyl sulfoxide; ethyl acetate;

DOI:10.1080/00397919808007167

Reference yield:

N-[(phenylmethoxy)carbonyl]-L-tyrosine (16679-94-0) + methyl iodide (74-88-4) → N-benzyloxycarbonylamino-3-(4-methoxyphenyl)propionic acid ethyl ester (115424-04-9)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; for 16h; Yield given; Ambient temperature;

DOI:10.1080/00397919808007167

upstream raw materials:

N-[(phenylmethoxy)carbonyl]-L-tyrosine

methyl iodide

L-tyrosine ethyl ester

O-Methyltyrosine

Downstream raw materials:

Toluene-4-sulfonic acid (S)-2-benzyloxycarbonylamino-3-(4-methoxy-phenyl)-propyl ester

N-Cbz-2-(4-methoxyphenyl)-1-methylethylamine

[(S)-1-Iodomethyl-2-(4-methoxy-phenyl)-ethyl]-carbamic acid benzyl ester

l-para-Methoxyamphetamine hydrochloride