(E)-4-(N-hydroxy-4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butylamino)-4-oxobut-2-enoic acid

Base Information

Chemical Name:(E)-4-(N-hydroxy-4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butylamino)-4-oxobut-2-enoic acid
CAS No.:1310809-17-6
Molecular Formula:C₂₇H₂₉N₃O₆
Molecular Weight:491.544
Hs Code.:

Synonyms:(E)-4-(N-hydroxy-4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butylamino)-4-oxobut-2-enoic acid

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Chemical Property of (E)-4-(N-hydroxy-4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butylamino)-4-oxobut-2-enoic acid

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Technology Process of (E)-4-(N-hydroxy-4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butylamino)-4-oxobut-2-enoic acid

There total 7 articles about (E)-4-(N-hydroxy-4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butylamino)-4-oxobut-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1310877-95-2
(E)-methyl 4-(N-hydroxy-4-(4-((naphthalen-1-yl-carbamoyloxy)methyl)benzylamino)butylamino)-4-oxobut-2-enoate

: 1310809-17-6
(E)-4-(N-hydroxy-4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butylamino)-4-oxobut-2-enoic acid

Guidance literature:: (E)-methyl 4-(N-hydroxy-4-(4-((naphthalen-1-yl-carbamoyloxy)methyl)benzylamino)butylamino)-4-oxobut-2-enoate; With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/ja201597b

Reference yield:

: 1310809-33-6
4-(hydroxymethyl)benzyl naphthalen-1-ylcarbamate

: 1310809-17-6
(E)-4-(N-hydroxy-4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butylamino)-4-oxobut-2-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: dipyridinium dichromate / dichloromethane / 5 h / Molecular sieve

2.1: acetic acid / methanol / 0.33 h

2.2: 20 °C

3.1: sodium hydroxide / tetrahydrofuran; water / 3 h / 20 °C

With dipyridinium dichromate; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ja201597b

Reference yield:

: 1310809-22-3
(E)-methyl 4-(benzoyloxy(4-(tert-butoxycarbonylamino)butyl)amino)-4-oxobut-2-enoate

: 1310809-17-6
(E)-4-(N-hydroxy-4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butylamino)-4-oxobut-2-enoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / methanol / 0.5 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

3.1: acetic acid / methanol / 0.33 h

3.2: 20 °C

4.1: sodium hydroxide / tetrahydrofuran; water / 3 h / 20 °C

With potassium carbonate; acetic acid; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ja201597b