(E)-methyl 4-(benzoyloxy(4-(tert-butoxycarbonylamino)butyl)amino)-4-oxobut-2-enoate

Base Information

Chemical Name:(E)-methyl 4-(benzoyloxy(4-(tert-butoxycarbonylamino)butyl)amino)-4-oxobut-2-enoate
CAS No.:1310809-22-3
Molecular Formula:C₂₁H₂₈N₂O₇
Molecular Weight:420.463
Hs Code.:

Synonyms:(E)-methyl 4-(benzoyloxy(4-(tert-butoxycarbonylamino)butyl)amino)-4-oxobut-2-enoate

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Chemical Property of (E)-methyl 4-(benzoyloxy(4-(tert-butoxycarbonylamino)butyl)amino)-4-oxobut-2-enoate

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Technology Process of (E)-methyl 4-(benzoyloxy(4-(tert-butoxycarbonylamino)butyl)amino)-4-oxobut-2-enoate

There total 5 articles about (E)-methyl 4-(benzoyloxy(4-(tert-butoxycarbonylamino)butyl)amino)-4-oxobut-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 2756-87-8
methyl hydrogen fumarate

: 1310809-19-8
tert-butyl (4-((benzoyloxy)amino)butyl)carbamate

: 1310809-22-3
(E)-methyl 4-(benzoyloxy(4-(tert-butoxycarbonylamino)butyl)amino)-4-oxobut-2-enoate

Guidance literature:: methyl hydrogen fumarate; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 0.833333h;

tert-butyl (4-((benzoyloxy)amino)butyl)carbamate; With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 2756-87-8
methyl hydrogen fumarate

: 1310809-22-3
(E)-methyl 4-(benzoyloxy(4-(tert-butoxycarbonylamino)butyl)amino)-4-oxobut-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.83 h / 0 - 20 °C

2: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C

With dmap; oxalyl dichloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja201597b

Reference yield:

: 68076-36-8
1-amino-4-[(tert-butyloxycarbonyl)amino]butane

: 1310809-22-3
(E)-methyl 4-(benzoyloxy(4-(tert-butoxycarbonylamino)butyl)amino)-4-oxobut-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate; sodium hydroxide / dichloromethane / 2.5 h

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.83 h / 0 - 20 °C

2.2: 2 h / 0 - 20 °C

With oxalyl dichloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane;