C₁₄H₁₇NO₄SSiC₆H₁₄C₂H₄O

Base Information

Chemical Name:C₁₄H₁₇NO₄SSiC₆H₁₄C₂H₄O
CAS No.:261156-82-5
Molecular Formula:C₂₂H₃₅NO₅SSi
Molecular Weight:453.675
Hs Code.:

C<sub>14</sub>H<sub>17</sub>NO<sub>4</sub>SSiC<sub>6</sub>H<sub>14</sub>C<sub>2</sub>H<sub>4</sub>O

Synonyms:C₁₄H₁₇NO₄SSiC₆H₁₄C₂H₄O

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Chemical Property of C₁₄H₁₇NO₄SSiC₆H₁₄C₂H₄O

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Technology Process of C₁₄H₁₇NO₄SSiC₆H₁₄C₂H₄O

There total 12 articles about C₁₄H₁₇NO₄SSiC₆H₁₄C₂H₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 107-21-1
ethylene glycol

: 261157-05-5
(1R,5R)-1-(tert-Butyl-dimethyl-silanyloxy)-6-(toluene-4-sulfonyl)-6-aza-bicyclo[3.2.1]octan-2-one

: 261156-82-5
C₁₄H₁₇NO₄SSiC₆H₁₄C₂H₄O

Guidance literature:: With toluene-4-sulfonic acid; In benzene; Heating;
DOI:10.1002/(SICI)1521-3773(20000103)39

Reference yield:

: 261156-79-0
(E)-3-[(2S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-acrylonitrile

: 261156-82-5
C₁₄H₁₇NO₄SSiC₆H₁₄C₂H₄O

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / H₂ / Pd/C / ethyl acetate / 12 h / 760.05 Torr

2: 100 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

3: 84 percent / Jones reagent / acetone / 0.5 h / 20 °C

4: 78 percent / SmI₂; MeOH / tetrahydrofuran / -78 - 20 °C

5: 91 percent / DIPEA / CH₂Cl₂ / 17 h / 0 - 20 °C

6: 100 percent / p-TsOH*H₂O / benzene / 15 h / Heating

With methanol; jones reagent; samarium diiodide; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; acetone; benzene; 1: Catalytic hydrogenation / 2: desilylation / 3: Oxidation / 4: Cyclization / 5: Condensation / 6: cyclocondensation;
DOI:10.1021/jo000260z

Reference yield:

: 261156-80-3
3-[(R)-4-Oxo-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionitrile

: 261156-82-5
C₁₄H₁₇NO₄SSiC₆H₁₄C₂H₄O

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / SmI₂; MeOH / tetrahydrofuran / -78 - 20 °C

2: 91 percent / DIPEA / CH₂Cl₂ / 17 h / 0 - 20 °C

3: 100 percent / p-TsOH*H₂O / benzene / 15 h / Heating

With methanol; samarium diiodide; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; benzene; 1: Cyclization / 2: Condensation / 3: cyclocondensation;
DOI:10.1021/jo000260z